226698-95-9

Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-1-(4-chlorophenyl)-2-propynylamine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (+/-)-1-(4-chlorophenyl)-2-propynylamine is utilized in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties make it a valuable component in the development of effective and targeted agrochemical products.
Used as a Monoamine Oxidase B Inhibitor:
(+/-)-1-(4-chlorophenyl)-2-propynylamine acts as a selective, irreversible, and monoamine oxidase B (MAO-B) inhibitor. This property has been investigated for its potential in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by the loss of dopamine-producing neurons. By inhibiting MAO-B, the compound can help to reduce the breakdown of dopamine in the brain, thereby potentially improving the symptoms of Parkinson's disease.
Used for Neuroprotective and Anti-Inflammatory Properties:
Research has also explored the neuroprotective and anti-inflammatory properties of (+/-)-1-(4-chlorophenyl)-2-propynylamine. These properties suggest that the compound may have potential applications in the treatment of other neurological disorders and conditions characterized by inflammation and oxidative stress in the brain.

Upstream product

• 226698-90-4 (+/-)-N-[1-(4-chlorophenyl)-2-propynyl]acetamide 
• 104-88-1 4-chlorobenzaldehyde 
• 29805-11-6 1-(4-chlorophenyl)prop-2-yn-1-ol 

Downstream Products

• 226699-02-1 (S)-1-(4-chlorophenyl)-2-propynylamine 
• 251093-10-4 (R)-N-acetyl-1-(4-chlorophenyl)prop-2-ynylamine 
• 249297-76-5 N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-N-(2,2-dimethoxy-ethyl)-formamide 
• 249297-77-6 N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-N-(2,2-dimethoxy-ethyl)-formamide 
• 249297-74-3 [(S)-Benzofuran-2-yl-(4-chloro-phenyl)-methyl]-(2,2-dimethoxy-ethyl)-amine 
• 249297-75-4 [(R)-Benzofuran-2-yl-(4-chloro-phenyl)-methyl]-(2,2-dimethoxy-ethyl)-amine 
• 249297-72-1 C-benzofuran-2-yl-C-(4-chloro-phenyl)-methylamine 
• 249297-73-2 (R)-C-benzofuran-2-yl-C-4-chlorophenyl-methylamine 

Relevant academic research and scientific papers

Benzodiazepines HDM2 inhibitor as well as preparation method and application thereof

The invention relates to a benzodiazepines compound, a preparation method of the benzodiazepines compound and medical application of the benzodiazepines compound, in particular to application of the benzodiazepines compound as a HDM2 inhibitor in treatmen

Silver-Catalyzed Synthesis of Substituted Pyridine Derivatives from N-Propargylic α-Enamino Esters

A wide range of substituted pyridine derivatives were synthesized in moderate to good yields from N-propargylic α-enamino esters. The synthetic strategy involved regioselective addition of a propargylamine to the α-carbon atom of an alkynyl ester to produce the N-propargylic α-enamino ester, which acted as the key intermediate in the synthesis.

Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents

Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(I)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents.

Microwave-assisted ethylene-alkyne cross-metathesis: Synthesis of chiral 2-(N-1-acetyl-1-arylmethyl)-1,3-butadienes

Chiral 1-arylpropargyl amides, which are resistant to undergoing ethylene-alkyne cross-metathesis at atmospheric pressure, were reacted under microwave irradiation to afford enantiomerically enriched 2-(N-1-acetyl-1- arylmethyl)-1,3-butadienes within a fe