249297-73-2

Upstream product

• 533-58-4 2-Iodophenol 
• 226699-15-6 (R)-1-(4-chlorophenyl)-2-propynylamine 
• 226699-02-1 (S)-1-(4-chlorophenyl)-2-propynylamine 
• 226698-95-9 (+/-)-1-(4-chlorophenyl)-2-propynylamine 

Downstream Products

• 249297-75-4 [(R)-Benzofuran-2-yl-(4-chloro-phenyl)-methyl]-(2,2-dimethoxy-ethyl)-amine 
• 336850-32-9 (S)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine 
• 352285-41-7 {3-[({[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-carbamoyl}-methyl)-tert-butoxycarbonyl-amino]-propyl}-carbamic acid tert-butyl ester 
• 249297-77-6 N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-N-(2,2-dimethoxy-ethyl)-formamide 

Relevant academic research and scientific papers

Stereoselective synthesis of α-aryl-2-benzofuranmethanamines and α- aryl-1H-indole-2-methanamines through palladium-mediated annulation of chiral α-arylpropargylamines

The title compounds, valuable chiral synthons for the synthesis of biologically active compounds, have been prepared in good yield and with high stereoselectivity through palladium-catalyzed heteroannulation of 2- iodophenol or 2-iodo-N-mesylaniline with

Chiral azole derivatives, 31. Synthesis of the enantiomers of the potent aromatase inhibitor 1-[2-benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole

Starting from (+)- and (-)-1-(4-chlorophenyl)-2-propynylamine, in turn obtained by CAL-mediated kinetic resolution of the corresponding racemate, a stereoselective synthesis of both enantiomers of the title compound has been achieved.