22676-72-8

Upstream product

• 463-71-8 thiophosgene 
• 623-04-1 4-aminobenzenemethanol 
• 75-15-0 carbon disulfide 
• 1877-77-6 3-aminobenzenemethanol 

Downstream Products

• 451471-21-9 4-isothiocyanatobenzyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 

Relevant academic research and scientific papers

2-AMINOQUINAZOLINONE DERIVATIVE

The present invention provides a 2-aminoquinazolinone derivative. The present invention is a compound represented by formula (1) [wherein X1 represents CR or N, X2 represents CR2 or N, X3 represents CR3 or N, Y represents an optionally substituted C6-10 aryl or optionally substituted 6 to 10-membered heteroaryl, Z represents an optionally substituted C6-10 aryl, RA represents a hydrogen atom, halogen, cyano, optionally substituted C1-6 alkyl sulfonyl, optionally substituted C1-6 alkyl, or optionally substituted C1-6 alkoxy, and R1, R2, and R3 independently represent a hydrogen atom, halogen, optionally substituted C1-6 alkyl, or optionally substituted C1-6 alkoxy] or a pharmaceutically acceptable salt thereof.

Hydrogen sulfide donor Preparation method and application thereof

The invention relates to a hydrogen sulfide donor, a preparation method and application thereof, and belongs to the technical field of molecular biology. The invention provides a hydrogen sulfide donor which has the structure represented by the following general formula I, wherein R is - NCS, OOOOOCCH is CH2 . One of the following. The hydrogen sulfide donor provided by the invention has the advantages of single release path, high release efficiency and the like, and can also realize visualization of hydrogen sulfide release through near-infrared fluorescence response.

Five-membered heterocycle substituted biphenyl compound and preparation method and application thereof

The invention discloses an immune checkpoint inhibitor five-membered heterocycle substituted biphenyl compound capable of blocking a PD-1/PD-L1 signal pathway and a preparation method and application thereof. The compound is shown in the formula I as described in the specification. The compound is novel in structure and can be orally taken, the defects of treatment and drug resistance of a monoclonal antibody immune checkpoint inhibitor are overcome, and as a small-molecule inhibitor, the preparation is simple, and industrial production is convenient; various related tumor diseases can be treated through tumor immunotherapy by regulating and controlling a PD-1/PD-L1 signal pathway, and potential patent medicine prospects are achieved.

Phenyl-substituted five-membered heterocyclic compounds as well as preparation method, application and pharmaceutical composition thereof

The invention discloses immune checkpoint inhibitor phenyl-substituted five-membered heterocyclic compounds capable of blocking a PD-1/PD-L1 signal path as well as a preparation method, application and a pharmaceutical composition thereof. The phenyl-substituted five-membered heterocycle compounds are shown as a formula I. The phenyl-substituted five-membered heterocycle compounds or pharmaceutically acceptable salts, racemates, optical isomers or solvent compounds thereof are disclosed.