2268-77-1

Usage

Uses

Used in Rubber Industry:
4-Methyl-2-mercaptobenzothiazole is used as an intermediate and anti-rust agent for enhancing the durability and performance of rubber products. Its application in this industry is crucial for preventing rust and corrosion, thereby extending the lifespan of rubber goods.
Used in Chemical Synthesis:
As an intermediate, 4-Methyl-2-mercaptobenzothiazole plays a significant role in the synthesis of various chemical compounds. Its unique structure allows it to be a key component in the production of a range of products, contributing to the chemical industry's diversity and innovation.
Environmental Health Concerns:
While 4-Methyl-2-mercaptobenzothiazole has its applications, it is also a chemical of concern due to its moderate toxicity to aquatic life and potential for bioaccumulation. This makes it essential to manage its use and disposal carefully to minimize its impact on the environment and human health.

InChI:InChI=1/C8H7NS2/c1-5-3-2-4-6-7(5)9-8(10)11-6/h2-4H,1H3,(H,9,10)

Upstream product

• 75-15-0 carbon disulfide 
• 86749-03-3 6,6′-disulfanediylbis(2-methylaniline) 

Downstream Products

• 52904-73-1 4-methyl-benzothiazole-2-sulfenic acid cyclohexylamide 
• 1477-42-5 4-methyl-1,3-benzothiazol-2-amine 
• 1448856-31-2 2-(phenylthio)-4-methylbenzo[d]thiazole 
• 20174-68-9 4-methyl-2-hydrazinobenzothiazole 
• 3622-20-6 4-methyl-2-methylsulfanyl-1,3-benzothiazole 

Relevant academic research and scientific papers

Highly efficient synthesis of 2-mercaptobenzothiazole derivatives in water: Metal sulfide-disulfide dynamic interchange reaction

A convenient and efficient method for the synthesis of 2-mercaptobenzothiazoles from disulfide and CS2 mediated by a metal sulfide in water is described. This synthetic methodology could be used to prepare diverse 2-mercaptobenzothiazole derivatives in good to excellent yields. In this paper, the concept of metal sulfide-disulfide dynamic interchange reaction was put forward. Then the intermediates of the interchange reaction between NaHS and a disulfide were detected by LC-MS, which demonstrated that the S-S bond of the disulfide could be broken by the metal sulfide through the dynamic interchange reaction. In addition, NaHS was eventually transformed into sulfur S8 by the dynamic interchange reaction. Moreover, the underlying mechanism of 2-mercaptobenzothiazole formation is proposed, in which NaHS not only acts as an S-S bond cleaving agent but also as an activator of CS2. As a result, a novel synthetic route for the preparation of sulfur-containing heterocycles from a disulfide is developed.

Compounds for the modulation of PPARgamma activity

Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.