20174-68-9Relevant articles and documents
The syntheses and crystal structure of novel 5-methyl-3-substituted-1,2,4-triazolo[3,4-b]benzothiazoles
Dong, Heng-Shan,Quan, Bin,Chai, Er-Feng,Mao, Xue-Rong
, p. 41 - 47 (2002)
Novel 5-methyl-3-substituted-1,2,4-triazolo[3,4-b]benzothiazoles were synthesized from o-methylaniline to 5 with various aromatic carbonic acids. The yielded product 6a-e were confirmed by Elemental Analyses, NMR, MS, IR spectra and 6e was investigated with X-ray crystallography. Compound 6e, C24H16N4S, Mr = 392.69, crystallized in the triclinic space group P1? with unit cell parameters a = 9.713(3) ?, b = 14.645(4) ?, c = 15.641(3) ?, α = 113.17(2)°, β=90.11(2)°, γ = 109.29(2)°, V = 1908.1(7) ?3, Z = 4, Dm = 1.366 Mgm-3.
Method for synthesizing 4-methyl-2-benzothiazolehydrazine
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, (2020/07/12)
The invention discloses a method for synthesizing 4-methyl-2-benzothiazolehydrazine. The method comprises the following steps: carrying out synthesis reaction on o-toluidine and thiocyanate in acid toobtain o-tolylthiourea; carrying out a synthesis reaction on the o-tolylthiourea and a catalyst in water to obtain 2-amino-4-methylbenzothiazole; and carrying out a synthesis reaction on the 2-amino-4-methylbenzothiazole in hydrazine hydrate, so as to obtain the 4-methyl-2-benzothiazolehydrazine. The method for synthesizing the 4-methyl-2-benzothiazolehydrazine, provided by the invention, is simple to operate, less in three wastes, capable of repeatedly applying wastewater, high in product content, good in quality and suitable for industrial mass production.
CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
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Paragraph 1386, (2018/04/17)
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.