Journal of Medicinal Chemistry p. 5884 - 5887 (2005)
Update date:2022-08-03
Topics:
Chackalamannil, Samuel
Xia, Yan
Greenlee, William J.
Clasby, Martin
Doller, Darìo
Tsai, Hsingan
Asberom, Theodros
Czarniecki, Michael
Ahn, Ho-Sam
Boykow, George
Foster, Carolyn
Agans-Fantuzzi, Jacqueline
Bryant, Matthew
Lau, Janice
Chintala, Madhu
Structurally novel thrombin receptor (protease activated receptor 1, PAR-1) antagonists based on the natural product himbacine are described. The prototypical PAR-1 antagonist 55 showed a Ki of 2.7 nM in the binding assay, making it the most po
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