226920-45-2Relevant academic research and scientific papers
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment
Weinstein, David S.,Liu, Wen,Ngu, Khehyong,Langevine, Charles,Combs, Donald W.,Zhuang, Shaobin,Chen, Cindy,Madsen, Cort S.,Harper, Timothy W.,Robl, Jeffrey A.
, p. 5115 - 5120 (2008/12/20)
A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian 15-lipoxygenase (15-LO) with excellent selectivity over human isozymes 5- and P-12-LO. Non-symmetrical sulfamides (e.g., 21a-n) were found to be suitable r
Imidazolyl inhibitors of 15-lipoxygenase
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Page/Page column 55, (2010/02/11)
The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.
A flexible, convergent approach to piperidines, pyridines, azepines, and related derivatives
Boivin, Jean,Pothier, Julien,Zard, Samir Z.
, p. 3701 - 3704 (2007/10/03)
A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.
