949-06-4

Basic information

• Product Name: 5-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPENTANE
• Synonyms: 5-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPENTANE
• CAS NO: 949-06-4
• Molecular Formula: C₁₂H₁₅ClO₂
• Molecular Weight: 226.7
• Mol File: 949-06-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 357.051°C at 760 mmHg
• Flash Point: 146.821°C
• Appearance: /
• Density: 1.101g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 5-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPENTANE(949-06-4)
• EPA Substance Registry System: 5-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPENTANE(949-06-4)

Safety Data

• Hazardous Substances Data: 949-06-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15ClO2/c1-15-11-7-5-10(6-8-11)12(14)4-2-3-9-13/h5-8H,2-4,9H2,1H3

Upstream product

• 120-92-3 cyclopentanone 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 100-66-3 methoxybenzene 
• 6280-87-1 δ-chlorovaleronitrile 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 1119-46-6 5-chloro-valeric acid 

Downstream Products

• 26954-35-8 1-(4-methoxyphenyl)pent-4-en-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 226920-45-2 4-phthalimido-1-(4'-methoxy-phenyl)-pentan-1-one 

Relevant articles and documents

Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O-H Bonds

We report a new photocatalytic protocol for the redox-neutral isomerization of cyclic alcohols to linear ketones via C-C bond scission. Mechanistic studies demonstrate that key alkoxy radical intermediates in this reaction are generated via the direct homolytic activation of alcohol O-H bonds in an unusual intramolecular PCET process, wherein the electron travels to a proximal radical cation in concert with proton transfer to a weak Br?nsted base. Effective bond strength considerations are shown to accurately forecast the feasibility of alkoxy radical generation with a given oxidant/base pair.

THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP

A compound of formula (I) in which R is lower alkyl, halogen, optionally substituted heterocyclic group or optionally substituted aryl, R is carboxy, protected carboxy or amidated carboxy, Ar is optionally substituted aryl or optionally substituted heterocyclic group, A is lower alkylene, X is oxa or a single bond, Y is thia, sulfinyl or sulfonyl, Z is methylene, thia, sulfinyl or sulfonyl, m and n are each an integer of 0 to 6, and 1/=m+n/=6, or its salt, which is useful as an inhibitor of matrix metalloproteinases (MMP) or tumor necrosis factor alpha (TNF alpha ).

Synthesis and some properties of 6-(ω-aroylbutylthio)purines

A series of 6-(ω-aroylthio)purines, which have not been described in the literature, has been obtained by the reaction of 6-purinethione with ω-chlorovalerophenone and its substituted derivatives. Some properties of the compounds synthesized have been studied, viz. reaction at the carbonyl group, methylation, and hydrolysis. 1999 KluwerAcademic/Plenum Publishers.