226943-07-3

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 
• 487-89-8 Indole-3-carboxaldehyde 
• 82980-12-9 3-ethenyl-1-phenylsulfonyl-1H-indole 

Downstream Products

• 226943-10-8 3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 226943-09-5 3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

cis- and trans-3-(3-indolyl)proline derivatives as conformationally restricted analogues of tryptophan

A method for the diastereoselective generation of 3-indolyl-3-proline derivatives has been developed. The [3+2] cycloaddition reaction of 3- vinylindoles with dimethyl N-ethoxycarbonyl-N-methoxymethylaminomalonate in the presence of TiCl4, afforded the title compounds after acid hydrolysis and decarboxylation reactions. These new amino acids may be viewed as conformationally restricted mimetics of tryptophan.

Synthesis of novel proline and γ-lactam derivatives as non-peptide mimics of Somatostatin/Sandostatin

Original proline or γ-lactam derivatives bearing either an aryl group such as a phenyl or a 3-indolyl in position 3 of the proline moiety or on the 3-methyl chain of the γ-lactam skeleton were prepared as non-peptide mimics of Somatostatin/Sandostatin.