227006-86-2Relevant academic research and scientific papers
Regioselective Hydroformylation of Enynes Catalyzed by a Zwitterionic Rhodium Complex and Triphenyl Phosphite
Van Den Hoven, Bernard G.,Alper, Howard
, p. 3964 - 3968 (1999)
The reaction of aliphatic 1-en-3-ynes with synthesis gas in the presence of the zwitterionic rhodium complex (η6-C6H5BPh3)-Rh +(1,5-COD) and triphenyl phosphite affords formyl dienes in high stereoselectivity. This catalytic system provides a useful method for the hydroformylation of both nonfunctionalized and functionalized conjugated enynes under mild conditions, affording formyl dienes in moderate to good yields.
Synthesis of Highly Substituted Pyridines via [4 + 2] Cycloadditions of Vinylallenes and Sulfonyl Cyanides
Bartko, Samuel G.,Hamzik, Phillip J.,Espindola, Leandro,Gomez, Christian,Danheiser, Rick L.
, p. 548 - 563 (2020)
A convergent strategy for the synthesis of multisubstituted pyridines is described. Vinylallenes combine with commercially available arylsulfonyl cyanides in Diels-Alder cycloadditions to generate isopyridine cycloadducts that are converted to pyridines upon further heating or addition of a base. The 2-sulfonylpyridine products undergo nucleophilic aromatic substitution reactions with oxygen and carbon nucleophiles to provide access to a variety of highly substituted pyridines.
