22718-22-5

Upstream product

• 108-94-1 cyclohexanone 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 

Downstream Products

• 771-98-2 1-Phenylcyclohexene 
• 1573114-54-1 butyl (E)-3-(2-((dimethylcarbamoyl)oxy)cyclohex-1-en-1-yl)acrylate 
• 13314-74-4 N,N-dimethyl-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-4-amine 
• 20758-60-5 1-(4-methoxyphenyl)cyclohexene 
• 78329-40-5 2-(cyclohex-1-en-1-yl)-1H-indole 

Relevant academic research and scientific papers

External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines

A visible-light-mediated synthesis of valuable polycyclic indolizine heterocycles from easily accessed brominated pyridine and enol carbamate derivatives has been developed. This process, which operates at room temperature under irradiation from readily available light sources, does not require the addition of an external photocatalyst. Instead, an investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation. Preliminary studies also show that these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.

Using Rh(III)-catalyzed C-H activation as a tool for the selective functionalization of ketone-containing molecules

Due to the strong potential of C-H activation in many areas of organic chemistry, the use of a pre-existing carbonyl group for the installation of a directing group to enable selective and predictable α-alkenylation with activated olefins as coupling partners is described. This Heck-type reaction would then lead either to β,γ-unsaturated ketones or to variously substituted 1,4-butadienes depending on the conditions used for the cleavage of the directing group.

Nickel-catalyzed efficient and practical Suzuki-Miyaura coupling of alkenyl and aryl carbamates with aryl boroxines

(Figure Presented) Suzuki-Miyaura coupling of unactivated alkenyl carbamates Is described to construct polysubstituted olefins. The developed process is also suitable for heteroaromatic and even electron-rich aromatic carbamates.