22718-48-5

Basic information

• Product Name: 1-methylhydrazinecarboxamide
• CAS NO: 22718-48-5
• Molecular Formula: C₂H₇N₃O
• Molecular Weight: 89.0965
• Mol File: 22718-48-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 190.1°C at 760 mmHg
• Flash Point: 68.8°C
• Density: 1.215g/cm³
• Vapor Pressure: 0.551mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 1-methylhydrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylhydrazinecarboxamide(22718-48-5)
• EPA Substance Registry System: 1-methylhydrazinecarboxamide(22718-48-5)

Safety Data

• Hazardous Substances Data: 22718-48-5(Hazardous Substances Data)

Usage

General Description

1-methylhydrazinecarboxamide, also known as mecarzine, is a chemical compound with the molecular formula C2H6N4O. It is a derivative of hydrazine and is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. Mecarzine is a white crystalline powder that is soluble in water and has a melting point of around 152-154°C. It is known for its vasodilator and diuretic properties, and has been used in the treatment of cardiovascular diseases and hypertension. Additionally, mecarzine has been studied for its potential antihypertensive, antitumor, and antiparasitic effects, making it a versatile and valuable chemical in the pharmaceutical industry.

Upstream product

• 590-28-3 potassium cyanate 
• 302-15-8 methylhydrazine sulfuric acid 
• 60-34-4 methylhydrazine 
• 1118-02-1 trimethylsilyl isocyanate 
• 917-61-3 sodium isocyanate 
• 7664-93-9 sulfuric acid 
• 684-93-5 1-methyl-1-nitrosourea 
• 64-19-7 acetic acid 

Downstream Products

• 4114-33-4 methyl-hydrazine-N,N'-dicarboxylic acid diamide 
• 16813-40-4 1,4-Dimethylbiurea 
• 343314-82-9 5-(difluoromethyl)-1,2-dihydro-2-methyl-3H-1,2,4-(triazol)-3-one 
• 1380401-00-2 N-(benzyloxycarbonyl)glycyl-azaalanine-amide 
• 6623-86-5 2-methyl-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid ethyl ester 
• 3190-40-7 2-Methyl-semicarbazid-di-carbimidsaeure-(1,1)-bis-(2,4-dimethyl-phenylester) 
• 3190-42-9 2-Methyl-semicarbazid-dicarbimidsaeure-(1.1)-bis-(3-chlorphenylester) 
• 3190-41-8 2-Methylsemicarbazid-dicarbimidsaeure-(1,1)-bis-p-tolylester 
• 18510-97-9 2-methyl-5,6-diphenyl-1,2,4-triazin-3(2H)-one 
• 21009-76-7 benzaldehyde-(2-methyl semicarbazone) 
• 54034-38-7 1-methyl-3-phenyl-Δ³-1,2,4-triazolin-5-one 

Relevant articles and documents

Methylsemicarbazide as a Ligand in Late 3d Transition Metal Complexes

Most ignition and initiation systems nowadays still contain poisonous chemicals such as lead styphnate and lead azide but also chromates and other compounds of high concern. Therefore, methylsemicarbazide (1, MSC), which can be prepared in a one-step reaction and in an extraordinary high yield of 95 %, has been evaluated as ligand in energetic coordination compounds. For the first time 25 new transition metal complexes (Mn2+, Ni2+, Co2+, Cu2+, and Zn2+) using methylsemicarbazide (1) as the ligand were prepared and comprehensively analyzed by, for example, XRD, IR, EA, UV/Vis and DSC/DTA/TGA. Many show a strong energetic character, which can be tuned by using different anions such as Cl?, SO42?, NO3?, ClO4?, picrate or styphnate. Selected compounds were additionally evaluated as lead-free primary explosives in initiation tests (nitropenta filled detonators) and in laser ignition systems. Especially compound 7 showed very promising results during these tests and could be a potential candidate for future applications.

INHIBITORS OF MALT1 PROTEASE

The present invention relates to compounds which are inhibitors of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALTl) and to their use in therapy, in particular in the treatment or prevention of a disease or disorder which is treatable by an inhibitor of a paracaspase. The present invention also relates to pharmaceutical compositions containing such compounds.

6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES

Disclosed are compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in particular herbicides. The compounds are triazine derivatives repres