54034-38-7

Upstream product

• 21009-76-7 benzaldehyde-(2-methyl semicarbazone) 
• 50369-47-6 1-methyl-5-(methylthio)-3-phenyl-1H-1,2,4-triazole 
• 39696-48-5 2-methyl-5-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 16219-34-4 N,N-dimethyl-3-phenyl-1,2,4-oxadiazol-5-amine 
• 74-89-5 methylamine 
• 16219-33-3 5-methylamino-3-phenyl-1,2,4-oxadiazole 
• 3663-37-4 3-phenyl-1,2,4-oxadiazol-5-amine 
• 129521-39-7 1-methyl-5-(methylsulfonyl)-3-phenyl-1H-1,2,4-triazole 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 825-60-5 benzimidic acid ethyl ester 
• 101934-62-7 Ethyl N-(methoxycarbonyl)-benzenecarboximidate 
• 60-34-4 methylhydrazine 
• 78414-66-1 1-methyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)hydrazine 
• 22718-48-5 2-methyl semicarbazide 

Relevant academic research and scientific papers

Photoinduced molecular rearrangements. The photochemistry of some 1,2,4-oxadiazoles in the presence of nitrogen nucleophiles. Formation of 1,2,4-triazoles, indazoles, and benzimidazoles

The photochemistry of some 3,5-disubstituted 1,2,4-oxadiazoles in the presence of nitrogen nucleophiles [external, such as added amines or hydrazines, or internal, such as an o-aminophenyl moiety at C(3) of the oxadiazole ring] has been investigated. In the irradiation of 5-amino-(or 5-N-substituted amino) 3-phenyl-1,2,4-oxadiazoles in the presence of aliphatic primary amines (or ammonia), photolytic species arising from heterolytic cleavage of the ring O-N bond capture the nucleophilic reagent to give open-chain intermediates, which develop into 1,2,4-triazolin-5-ones. Similarly, irradiations of 3,5-diphenyl-, 3-methoxy-5-phenyl-, and 5-methyl-3-phenyl-1,2,4-oxadiazoles gave 1,2,4-triazoles. In the same context, irradiations of representative substrates in the presence of hydrazines have been also investigated. In the irradiation of 3-(o-aminophenyl)-5-methyl-, 3-[o-(methylamino)phenyl]-5-methyl-, and 3-(o-aminophenyl)-5-phenyl-1,2,4-oxadiazoles, concomitant formation of indazoles and benzimidazoles, presumably arising from a common photolytic species, has been observed. Some mechanistic aspects have been considered, and possible applications in synthesis have been pointed out.

2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents

A series of 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones was evaluated for anticonvulsant activity. In general the members of this series were prepared by the alkaline crystalization of 1-aroyl-4-alkylsemicarbazides. The resulting 2-unsubstituted 3H-1,2,4-t

Thermal Behaviour of 3-Phenyl-1,2,4-oxadiazol-5-ylhydrazines

Depending on the substitution on the hydrazine moiety, thermolysis of 3-phenyl-1,2,4-oxadiazol-5-ylhydrazines (1)-(5) gives variable amounts of 1-amino-Δ2-1,2,4-triazolin-5-ones (13) or (17), Δ2- or Δ3-1,2,4-triazolin-5-ones (12), (18), or (19), and the s-triazine (20).A possible mechanism accounting for the products and the effects is discussed.A diradical intermediate and a hydrogen transfer from the reaction medium are suggested on the basis of the effect of benzoyl peroxide on the reaction and on the behaviour of the hydrazines (1)-(4) towards catalytic hydrogenation.