227327-88-0Relevant academic research and scientific papers
Hit-to-Lead studies: The discovery of potent adamantane amide P2X 7 receptor antagonists
Baxter, Andrew,Bent, Janice,Bowers, Keith,Braddock, Martin,Brough, Steve,Fagura, Malbinder,Lawson, Mandy,McInally, Tom,Mortimore, Mike,Robertson, Mark,Weaver, Richard,Webborn, Peter
, p. 4047 - 4050 (2007/10/03)
A Hit-to-Lead optimisation programme was carried out on the adamantane high throughput screening hit 1 resulting in the discovery of a number of potent P2X7 antagonists.
Adamantane derivatives
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, (2008/06/13)
The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
