227449-46-9

Usage

Structure

Benzotriazole group, pyrimidine ring, and amide functional group

Application

Photoinitiator in polymer material formulation

Use in industry

Manufacturing of coatings, adhesives, and sealants

UV properties

Absorbs ultraviolet light

Polymerization process

Initiates when exposed to UV light

Pharmaceutical research

Potential use in cancer treatment

Enzyme inhibition

Inhibits specific kinase enzymes involved in cell proliferation and survival

Diverse applications

Material science and pharmaceutical research fields

Upstream product

• 227449-25-4 2-chloro-4-(4-methylanilino)pyrimidine-5-carboxylic acid 
• 2592-95-2 benzotriazol-1-ol 
• 227449-05-0 ethyl 2-chloro-4-(4-methylanilino)pyrimidine-5-carboxylate 
• 51940-64-8 ethyl 2,4-dichloropyrimidine-5-carboxylate 
• 106-49-0 p-toluidine 

Relevant academic research and scientific papers

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives

Spleen tyrosine kinase (Syk) is a non-receptor-type tyrosine kinase which mediates diverse responses in haematopoietic cells. Therefore, Syk is an attractive therapeutic target, and in a study of Syk inhibitors as potentially new therapeutic agents, we di