227466-91-3

Upstream product

• 955124-58-0 (R)-(+)-1-phenylpropylammonium (R)-(-)-chromane-2-carboxylate 
• 66598-81-0 chroman-2-carboxylic acid methyl ester 
• 83780-47-6 (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 4940-39-0 acide chromone carboxylique-2 
• 51939-71-0 chroman-2-carboxylic acid 

Downstream Products

• 1451374-16-5 methyl 5-((2R)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-2H-chromen-4-yl)-2-fluorobenzoate 
• 1451374-85-8 3-((2R,4S)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)-2,6-dimethylbenzoic acid 
• 1451372-04-5 methyl 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate 
• 1451372-05-6 methyl 2-fluoro-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate 
• 404337-71-9 (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanamine 
• 955124-60-4 (R)-tert-butyl (8-(2,6-dichlorophenyl)-2-chromanyl)methylcarbamate 
• 227296-56-2 (R)-1-[3-[[(3,4-dihydro-2H-1-benzopyran-2-yl)-methyl]amino]propyl]tetrahydro-2(1H)-pyrimidinone 
• 149177-75-3 (2R)-3,4-dihydro-2H-chromen-2-ylmethylamine hydrochloride 

Relevant academic research and scientific papers

SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS

The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF

Methods of preparing compounds of formula (I) or pharmaceutically acceptable salts thereof are provided wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Synthesis of optically active 6-substituted 2-(aminomethyl)chromans

Three novel, optically active, 6-substituted 2-(aminomethyl)chromans were synthesized from readily available chroman 2-carboxylic acid precursors. These chroman-containing primary amines are useful building blocks for the synthesis of chroman-derived phar