70292-11-4Relevant academic research and scientific papers
Organocatalytic 1,3-Dipolar Cycloaddition Reaction of β-Keto Amides with Azides - Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazole-4-carboxamides
Zhou, Xiao,Xu, Xianhong,Liu, Kun,Gao, Hua,Wang, Wei,Li, Wenjun
, p. 1886 - 1890 (2016)
Organocatalytic [3+2] 1,3-dipolar cycloaddition reactions of β-keto amides with azides catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) have been developed. This strategy generates 1,4,5-trisubstituted 1,2,3-triazole-4-carboxamides in high yields and
Synthetic method of 1,4,5-trisubstituted-1,2,3-triazole compound
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Paragraph 0028, (2016/10/07)
The invention discloses a synthetic method of a 1,4,5-trisubstituted-1,2,3-triazole compound. In a reaction solvent, acetoacetamide and nitrine are used as reaction materials and Lewis base is used as a catalyst to carry out a reaction so as to obtain a p
Intramolecular hydrogen bonding-assisted cyclocondensation of α-diazoketones with various amines: A strategy for highly efficient Wolff 1,2,3-triazole synthesis
Wang, Zikun,Bi, Xihe,Liao, Peiqiu,Zhang, Rui,Liang, Yongjiu,Dong, Dewen
supporting information; experimental part, p. 7076 - 7078 (2012/08/14)
A catalytic and highly efficient Wolff's cyclocondensation of α-diazoketones with aromatic and aliphatic amines has been realized for the first time by utilizing the strategy of an intramolecular hydrogen bonding-activating carbonyl group. This approach successfully solved the challenging problem of poor condensation efficiency in Wolff 1,2,3-triazole synthesis, and constitutes a powerful method for the synthesis of highly functionalized 1,2,3-triazoles. The Royal Society of Chemistry 2012.
