227758-97-6

Upstream product

• 154061-64-0 (2S)-2-<(Benzyloxycarbonyl)amino>-6-hydroxyhexanoic acid methyl ester 
• 110-87-2 3,4-dihydro-2H-pyran 
• 44601-24-3 4-hydroxypentanal 
• 121895-18-9 (S)-2-amino-6-hydroxyhexanoic acid methyl ester hydrochloride 
• 215054-80-1 (S)-2-amino-5-(1,3-dioxolane-2-yl)-pentanoic acid 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 852822-01-6 (S)-2-Benzyloxycarbonylamino-5-[1,3]dioxolan-2-yl-pentanoic acid 
• 824943-43-3 (S)-2-benzyloxycarbonylamino-5-(2-[1,3]dioxolanyl)-pentanoic acid methyl ester 

Downstream Products

• 117836-13-2 (S)-5-Oxo-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 917507-80-3 (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid 
• 117836-26-7 cis-5(S)-hydroxy-2(S)-N₁-benzyloxycarbonylpipecolic acid methyl ester 
• 63088-78-8 (2S,5R)-5-hydroxypiperidine-2-carboxylic acid 
• 189952-46-3 (2S,5R)-methyl 5-hydroxypiperidine-2-carboxylate 
• 824943-40-0 (2S,5R)-5-hydroxy-piperidine-2-carboxylic acid hydrochloride 
• 824943-60-4 (3S,4aR,10aR)-5,7-Dimethoxy-1,2,3,4a,9,10a-hexahydro-10-oxa-4-aza-phenanthrene-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester 
• 824943-58-0 (2S,5R)-5-(3,5-dimethoxy-benzyloxy)-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 852822-08-3 (2S,5R,6S)-5-Acetoxy-6-(2-oxo-2-phenyl-ethyl)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 824943-47-7 (2S,5R)-5-acetoxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant academic research and scientific papers

MANUFACTURING METHOD OF (2S,5S)-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID AS WELL AS MANUFACTURING INTERMEDIATE OF THE SAME AND METHOD FOR MANUFACTURING THE SAME

PROBLEM TO BE SOLVED: To provide synthesis methods of 5-hydroxy-6-methoxypiperidine-2-carboxylic acid derivatives and 5-oxopiperidine-2-carboxylic acid derivatives more safely than ever by using inexpensive raw ingredients. SOLUTION: In the provided method, a compound expressed by the following formula [X] is manufactured from a compound expressed by the following formula [I] through steps (1) through (9) [either steps (4) and (5) or steps (6) and (7) in the case of steps (4) through (7)]. COPYRIGHT: (C)2015,JPOandINPIT

Diastereoselective synthesis of (2Ss,5R)-5-hydroxypipecolic acid and 6-substituted derivatives

(Chemical Equation Presented) Herein, we report a diastereoselective synthesis of the natural product (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives thereof. The key step in the synthetic sequence is a novel highly diastereoselective epoxidation reaction of an enantiomerically pure cyclic enamide intermediate.