2279-10-9

Upstream product

• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 76413-59-7 [(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(2-thioxo-thiazolidin-3-yl)-ethyl]-carbamic acid benzyl ester 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 7451-73-2 (3S)-(1H-indol-3-ylmethyl)-piperazine-2,5-dione 
• 112689-73-3 N-L-tryptophyl-glycine benzyl ester; hydrochloride 
• 7360-09-0 L-tryptophyl-Glycine 
• 17388-70-4 (benzyloxycarbonyl)-L-tryptophylglycine 

Relevant academic research and scientific papers

Three types of induced tryptophan optical activity compared in model dipeptides: Theory and experiment

The tryptophan (Trp) aromatic residue in chiral matrices often exhibits a large optical activity and thus provides valuable structural information. However, it can also obscure spectral contributions from other peptide parts. To better understand the indu

A rapid and efficient synthesis of β-casomorphin employing Boc-amino acids and 9-fluorenylmethyl chloroformate as a coupling agent

The synthesis of β-casomorphin H-Tyr-Pro-Phe-Pro-Gly-OH employing Boc group for Nα-protection and 9-fluorenylmethyl chloroformate (Fmoc-Cl) for the formation of peptide bond is described. The protocol employing Fmoc-Cl as coupling reagent is found to be simple, efficient and rapid. All the intermediate peptides as well as the final protected peptide Boc-Tyr( iBu)-Pro-Phe-Pro-Gly-OMe have been isolated and fully characterized. They have been obtained in good yield and with high purity.

Simple synthesis of 1,3,4,5a,6,10b,11,11a-octahydro-2H-pyrazino[1′,2′:1,5]pyrrolo[2, 3-b]indole derivatives based on 1-hydroxyindole chemistry

3-Substituted (3S,6S)-6-(1-hydroxyindol-3-ylmethyl)-2,5-piperazinediones are prepared for the first time. They are shown to be suitable intermediates for the synthesis of 3,10b-disubstituted (3S,5aR,10bS,11as)-1,3,4,5a,6,10b,11, 11a-octahydro-2H-pyrazino[

Chlorosulfite, a Versatile and Mild Condensation Reagent for the Synthesis of Peptides

The title compound 5, which can be easily obtained from hexamethylphosphoric triamide (1) and thionyl chloride by catalysis of dimethylformamide, is succesfully applied as a mild condensation reagent for the synthesis of peptides.

Studies on Peptides. XCIV. Thiazoline-2-thione as a Carboxyl-activating Reagent for Peptide Synthesis

3-Acyl derivatives obtained from the DCC condensation of Nα-protected amino acids and thiazoline-2-thione were found to be useful for peptide synthesis, in the same way as active esters.Keywords---3-acylthiazoline-2-thione derivatives of N