227951-72-6Relevant academic research and scientific papers
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
Takamura, Fujiko,Tanaka, Akira,Takasugi, Hisashi,Taniguchi, Kiyoshi,Nishio, Mie,Seki, Jiro,Hattori, Kouji
, p. 4475 - 4478 (2007/10/03)
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI2 agonist activity and metabolically more stable than FK788.
Naphthalene derivatives
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, (2008/06/13)
A compound of formula (I), wherein R1is carboxy or protected carboxy, R2and R3are each independently hydrogen, hydroxy, or protected hydroxy, R4is hydrogen or halogen, R5is aryl substituted with halog
