13020-93-4Relevant academic research and scientific papers
FLUORINE RECOGNITION AT THE ACTIVE SITE OF (N-(4-FLUOROPHENYL)-N-PHENYLCARBAMOYL)-α-CHYMOTRYPSIN
Cairi, M.,Gerig, J. T.
, p. 3640 - 3643 (1984)
N-(4-fluorophenyl)-N-phenylcarbamoyl chloride reacts with α-chymotrypsin to give a covalenty modified protein which is devoid of catalytic activity.The fluorophenyl ring of this protein may be found in two magnetically distinct environments; fluorine chem
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
Takamura, Fujiko,Tanaka, Akira,Takasugi, Hisashi,Taniguchi, Kiyoshi,Nishio, Mie,Seki, Jiro,Hattori, Kouji
, p. 4475 - 4478 (2007/10/03)
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI2 agonist activity and metabolically more stable than FK788.
