2280-28-6

Basic information

• Product Name: (R)-2-Amino-3-hydroxy-3-methylbutanoic acid
• Synonyms: DL-BETA-HYDROXYVALINE;H-D-VAL(BETA-OH)-OH;BETA-HYDROXY-D-VALINE;(R,S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID;3-Hydroxy-D-Valine;D-SS-HYDROXYVALINE;3-Hydroxyvaline.;2-Amino-3-hydroxy-3-methylbutanoicacid
• CAS NO: 2280-28-6
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.15
• Product Categories: Amino Acid Derivatives;Chiral Reagent;Valine [Val, V]
• Mol File: 2280-28-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 200-202 °C
• Boiling Point: 245.66°C (rough estimate)
• Appearance: /
• Density: 1.2510 (rough estimate)
• Refractive Index: 1.4206 (estimate)
• CAS DataBase Reference: (R)-2-Amino-3-hydroxy-3-methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Amino-3-hydroxy-3-methylbutanoic acid(2280-28-6)
• EPA Substance Registry System: (R)-2-Amino-3-hydroxy-3-methylbutanoic acid(2280-28-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 2280-28-6(Hazardous Substances Data)

Usage

Chemical Properties

white fluffy shiny powder

InChI:InChI=1S/C5H11NO3/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)

Upstream product

• 14598-96-0 DL-N-Benzyl-β-hydroxyvalin 
• 7647-01-0 hydrogenchloride 
• 106272-96-2 3-acetyl-5,5-dimethyl-1,1-dioxo-2-phenyl-1λ⁶-thiazolidine-4-carboxylic acid 
• 541-47-9 3-Methylbutenoic acid 
• 10544-72-6 dinitrogen tetraoxide 
• 33550-36-6 Dimethyl-3,3 diethoxycarbonyl-1,2 aziridine 
• 75974-47-9 α-bromo-β-methoxy-isovaleric acid 
• 20836-49-1 ketene bis(trimethylsilyl) acetal 
• 67-64-1 acetone 
• 4374-53-2 3,3-dimethyl-oxirane-2-carboxylic acid 
• 32817-15-5 copper(II) glycinate 
• 33550-37-7 3-Acetoxy-2-ethoxycarbonylamino-3-methyl-butyric acid ethyl ester 
• 18801-86-0 2-amino-3-methoxy-3-methylbutanoic acid 

Downstream Products

• 21934-95-2 Zn(NC₅HO(CH₃)(CH₂OH)CHNCH₂CO₂)2^(2-) 
• 114835-63-1 N-pyridoxylideneglycine zinc(II) complex 
• 30487-93-5 Al(NC₅HO(CH₃)(CH₂OH)CHNCH₂CO₂)2^(1-) 
• 14599-02-1 N-benzoyl-3-chlorovaline methyl ester 
• 14599-01-0 α-benzoylamino-β-hydroxy-isovaleric acid methyl ester 
• 14599-03-2 methyl 2-benzamido-3-methylbutanoate 
• 2280-48-0 (R)-(-)-β-hydroxyvaline 
• 101115-49-5 N-acetyl-S-benzyl-DL-penicillamine 
• 159000-75-6 S-benzyl-D,L-penicillamine 
• 102507-19-7 (S)-tert-butyl 1-(benzyloxyamino)-3-hydroxy-3-methyl-1-oxobutan-2-ylcarbamate 
• 102507-25-5 (3S)-3-[(t-Butyloxycarbonyl)amino]-4,4-dimethyl-1-(phenylmethoxy)-2-azetidinone 
• 107982-90-1 ((S)-1-Benzyloxycarbamoyl-2-methyl-2-sulfooxy-propyl)-carbamic acid tert-butyl ester; compound with 2-methyl-pyridine 
• 107982-89-8 ((S)-1-Benzyloxycarbamoyl-2-methyl-2-sulfooxy-propyl)-carbamic acid tert-butyl ester; compound with pyridine 
• 516-06-3 D,L-valine 

Relevant articles and documents

Etude par la Modelisation Moleculaire de la Regioselectivite de l'Ouverture des Acides Glycidiques par les Amines Aliphatiques

A model for glycidic acids opening reaction by ammonia and amines has been suggested from semi-empiric orbital calculations.It provides a way for evaluating the different interactions between the incoming nucleophile and the oxirane substituents.Steric and coulombic interactions of the carboxylate in staggered conformation (cis substitution) has a major influence to rationalize experimental regioselectivity.

Synthesis of aliphatic 2-amino-3-hydroxy acids and separation of their diastereoisomers with the aid of copper chelates.

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