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758-08-7

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758-08-7 Usage

General Description

2-Mercaptoacetamide is a chemical compound with the formula C2H5NOS. It is a thiol derivative of acetamide and contains a sulfhydryl group, which makes it a versatile compound for various chemical reactions. 2-Mercaptoacetamide is commonly used as a chelating agent, especially in metal ions binding and removal. It is also used as a precursor in the preparation of pharmaceuticals and other organic compounds. Additionally, 2-Mercaptoacetamide has antimicrobial properties, making it useful in the production of antifungal and antibacterial agents. Its ability to form complexes with metal ions also makes it valuable in analytical chemistry and biochemical studies.

Check Digit Verification of cas no

The CAS Registry Mumber 758-08-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,5 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 758-08:
(5*7)+(4*5)+(3*8)+(2*0)+(1*8)=87
87 % 10 = 7
So 758-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H5NOS/c3-2(4)1-5/h5H,1H2,(H2,3,4)

758-08-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-sulfanylacetamide

1.2 Other means of identification

Product number -
Other names Acetamide,2-mercapto

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:758-08-7 SDS

758-08-7Relevant articles and documents

Investigation of (S)-(-)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

Bockman, Matthew R.,Engelhart, Curtis A.,Cramer, Julia D.,Howe, Michael D.,Mishra, Neeraj K.,Zimmerman, Matthew,Larson, Peter,Alvarez-Cabrera, Nadine,Park, Sae Woong,Boshoff, Helena I. M.,Bean, James M.,Young, Victor G.,Ferguson, David M.,Dartois, Veronique,Jarrett, Joseph T.,Schnappinger, Dirk,Aldrich, Courtney C.

, p. 598 - 617 (2019/02/14)

The synthesis, absolute stereochemical configuration, complete biological characterization, mechanism of action and resistance, and pharmacokinetic properties of (S)-(-)-acidomycin are described. Acidomycin possesses promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains (minimum inhibitory concentrations (MICs) = 0.096-6.2 μM) but is inactive against nontuberculosis mycobacteria and Gram-positive and Gram-negative pathogens (MICs > 1000 μM). Complementation studies with biotin biosynthetic pathway intermediates and subsequent biochemical studies confirmed acidomycin inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB) and also stimulates unproductive cleavage of S-adenosyl-l-methionine (SAM) to generate the toxic metabolite 5′-deoxyadenosine. Cell studies demonstrate acidomycin selectively accumulates in M. tuberculosis providing a mechanistic basis for the observed antibacterial activity. The development of spontaneous resistance by M. tuberculosis to acidomycin was difficult, and only low-level resistance to acidomycin was observed by overexpression of BioB. Collectively, the results provide a foundation to advance acidomycin and highlight BioB as a promising target.

Corresponding amine nitrile and method of manufacturing thereof

-

Paragraph 0138; 0139; 0140; 0147; 0148, (2018/05/07)

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

NOVEL THIAZINE OR PYRAZINE DERIVATIVES

-

, (2008/06/13)

An object of the present invention is to synthesize novel compounds having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine or 2-oxo-1, 2, 3, 4-tetrahydropyrazine as a main skeleton. The present invention relates to compounds represented by the following general formula [I] and salts thereof. In the formula, X is S or R6-(A2)n-N, R1 and R2 are H, alkyl, cycloalkyl or aryl, R3 and R4 are H, alkyl, cycloalkyl, aryl or aromatic heterocycles, R5 is H, alkyl, cycloalkyl, aryl or -A3-A4-R7, R6 is H, alkyl, cycloalkyl, OH, alkoxy, aryl, aryloxy or an aromatic heterocycle, R7 is H, alkyl, OH, alkoxy, aryl, aryloxy, amino, alkylamino, arylamino, an aromatic heterocycle or a nonaromatic heterocycle, A1 is alkylene, A2 is carbonyl or sulfonyl, A3 is alkylene, and A4 is carbonyl or oxalyl.

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