22813-58-7

Basic information

• Product Name: N,N-DIMETHYL-4-CHLOROBUTANAMIDE
• Synonyms: N,N-DIMETHYL-4-CHLOROBUTANAMIDE;4-chloro-N,N-dimethylbutyramide;butanamide, 4-chloro-N,N-dimethyl-;Einecs 245-244-0
• CAS NO: 22813-58-7
• Molecular Formula: C₆H₁₂ClNO
• Molecular Weight: 149.62
• EINECS: 245-244-0
• Mol File: 22813-58-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 221.4°Cat760mmHg
• Flash Point: 87.7°C
• Appearance: /
• Density: 1.043g/cm³
• Vapor Pressure: 0.108mmHg at 25°C
• Refractive Index: 1.449
• CAS DataBase Reference: N,N-DIMETHYL-4-CHLOROBUTANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-4-CHLOROBUTANAMIDE(22813-58-7)
• EPA Substance Registry System: N,N-DIMETHYL-4-CHLOROBUTANAMIDE(22813-58-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 22813-58-7(Hazardous Substances Data)

Usage

General Description

N,N-DIMETHYL-4-CHLOROBUTANAMIDE is a chemical compound with the molecular formula C6H12ClNO. It is a derivative of butyramide with a chlorine atom attached to the fourth carbon and two methyl groups attached to the nitrogen atom. N,N-DIMETHYL-4-CHLOROBUTANAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a solvent and reagent in organic synthesis. N,N-DIMETHYL-4-CHLOROBUTANAMIDE is known to have irritant properties and should be handled with care to avoid contact with skin, eyes, and mucous membranes.

InChI:InChI=1/C6H12ClNO/c1-8(2)6(9)4-3-5-7/h3-5H2,1-2H3

Upstream product

• 124-40-3 dimethyl amine 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 3153-36-4 4-chloro-butyric acid ethyl ester 
• 84738-97-6 methylchloroaluminum N,N-dimethylamide 
• 627-00-9 γ-chlorobutyric acid 
• 122368-54-1 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine 

Downstream Products

• 115178-78-4 Benzoic acid 3-dimethylcarbamoyl-propyl ester 
• 67446-96-2 N-(3',4'-dichlorophenyl)-N-(4-dimethylaminobutyl)propionamide 
• 129041-15-2 4-(N,N-Dibenzylamino)-N',N'-dimethylbutyramid 

Relevant articles and documents

Cyclic Oxonium Salts: 13C Magnetic Resonance Spectroscopy. The Correlation of Chemical Shifts with the Calculated Charge Density

The 13C chemical shifts of several bicyclic and monocyclic oxonium salts are reported and, in the case of 5-membered ring unsaturated oxonium salts, compared with ab initio and CNDO calculated charges.A prime dependence of the 13C shielding on the ? charge delocalization effects induced by the Y group is established for the Y-substituted C-α carbon; a good correlation of δC-α vs q? is obtained, using ? bond-order terms.However, contradictory information arises from NMR and theoretical calculations for the C-ω carbon, which is distant from the Y group.The results are discussed.

Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same

Disclosed is a compound represented by Formula (I): STR1 wherein Ar1, Ar2, n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical compositions containing the compound. The compound has an antihistamic and antiallergic effect.