22813-61-2

Upstream product

• 3153-36-4 4-chloro-butyric acid ethyl ester 
• 100-46-9 benzylamine 
• 19340-88-6 N-benzyl-4-hydroxybutanamide 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 136408-38-3 N-benzyl-4-iodobutanamide 
• 73963-33-4 1-Benzyl-5-(3-chloro-propyl)-1H-tetrazole 
• 136408-34-9 (Z)-N-benzyl 5,6-dicarbomethoxy-5-hexenamide 
• 950101-21-0 C₂₀H₁₉N₅OS 
• 181959-65-9 4-acetylthio-N-benzylbutyrylamide 
• 64017-86-3 N-benzyl-4-(benzylamino)butanamide 
• 5291-77-0 1-benzyl-2-pyrrolidone 

Relevant academic research and scientific papers

Identification of cell-active lysine specific demethylase 1-selective inhibitors

(Chemical Equation Presented) Lysine specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated Lys4 of histone H3 (H3K4). Here we report the identification of the first small-molecule LSD1-selective inhibitors. These inhibitors show in vivo H3K4-methylating activity and antiproliferative activity and should be useful as lead structures for anticancer drugs and as tools for studying the biological roles of LSD1.

Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral

A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method. The Royal Society of Chemistry.

Investigations into the mechanism of lactamization of lactones yielding in a novel route to biologically active tryptamine derivatives

The mechanism of lactamization of corresponding lactones was investigated by means of gas chromatography and synthesis of possible intermediates as references. Lactones react with amines via the amino acid with subsequent elimination of water to the corresponding lactams. In the first step, also hydroxyamides are in equilibrium with the lactones and amines, respectively, which are not able to form the amide though. This mechanism opens a new approach for the synthesis of Nβ-disubstituted tryptamines.

Preparation and reactivity of chiral β-amino-alkylzinc iodides and related configurationally stable zinc organometallics

Several zinc organometallics bearing at the β-position a carbamate or an amido function with an acidic N-H group were prepared using the direct insertion of zinc dust into the corresponding alkyl iodides in THF or THF:DMSO mixtures. Most of the starting iodides were obtained from natural α-amino acids and the resulting zinc species afforded after transmetalation with CuCN.2LiCl and reaction with a selection of relatively reactive electrophiles a variety of polyfunctional 1,2-amino alcohol derivatives and carbamates in optically pure form. Several secondary β-amido alkyl iodides were converted to the corresponding chiral zinc reagents and trapped with electrophiles. The configurational stability of chiral secondary organozinc compounds and the stereochemical course of their reactions were examined.