22821-15-4

Basic information

• Product Name: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole
• Synonyms: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole
• CAS NO: 22821-15-4
• Molecular Weight: 298.815
• Mol File: 22821-15-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole(22821-15-4)
• EPA Substance Registry System: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole(22821-15-4)

Safety Data

• Hazardous Substances Data: 22821-15-4(Hazardous Substances Data)

Upstream product

• 60274-60-4 1-chloro-5-iodopentane 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 95-54-5 1,2-diamino-benzene 
• 65-85-0 benzoic acid 

Downstream Products

• 1081111-11-6 2-phenyl-1-{5-[4-(3-acetylaminophenyl)piperidin-1-yl]pentyl}-1H-benzimidazole 

Relevant articles and documents

Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists

Compounds containing 2-arybenzimidazole ring systems linked to arylpiperidines were synthesized and evaluated as MCH-R1 antagonists. The results of structure-activity relationship studies led to the identification of compound 4c as a potent MCH-R1 antagonist (IC50 = 1 nM). This compound also has good metabolic stability, and favorable pharmacokinetic and brain penetration properties. However 4c was found to be potent inhibitor of the hERG potassium channel.