22821-15-4

Basic information

• Product Name: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole
• Synonyms: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole
• CAS NO: 22821-15-4
• Molecular Weight: 298.815
• Mol File: 22821-15-4.mol

Chemical Properties

• CAS DataBase Reference: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole(22821-15-4)
• EPA Substance Registry System: 1-(5-chloropentyl)-2-phenyl-1H-benzimidazole(22821-15-4)

Safety Data

• Hazardous Substances Data: 22821-15-4(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 95-54-5 1,2-diamino-benzene 
• 60274-60-4 1-chloro-5-iodopentane 
• 716-79-0 2-phenyl-1H-benzoimidazole 

Downstream Products

• 1081111-11-6 2-phenyl-1-{5-[4-(3-acetylaminophenyl)piperidin-1-yl]pentyl}-1H-benzimidazole 

Relevant articles and documents

Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists

Compounds containing 2-arybenzimidazole ring systems linked to arylpiperidines were synthesized and evaluated as MCH-R1 antagonists. The results of structure-activity relationship studies led to the identification of compound 4c as a potent MCH-R1 antagonist (IC50 = 1 nM). This compound also has good metabolic stability, and favorable pharmacokinetic and brain penetration properties. However 4c was found to be potent inhibitor of the hERG potassium channel.

IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.