60274-60-4

Basic information

• Product Name: 1-CHLORO-5-IODOPENTANE
• Synonyms: 1-CHLORO-5-IODOPENTANE;PENTAMETHYLENE CHLOROIODIDE;1-CHLORO-5-IODOPENTANE 97%;PENTAMETHYLENE CHLOROIODIDE 97%;1-Chloro-5-iodopentane,97%;1-Iodo-5-chloropentane;5-Chloropentyl iodide, 5-Iodopentyl chloride
• CAS NO: 60274-60-4
• Molecular Formula: C₅H₁₀ClI
• Molecular Weight: 232.49
• EINECS: 262-137-4
• Product Categories: Alkyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 60274-60-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 75-77°C 4mm
• Flash Point: 75-77°C/4mm
• Appearance: /
• Density: 1.663
• Vapor Pressure: 0.116mmHg at 25°C
• Refractive Index: 1.5305
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility: Not miscible or difficult to mix with water.
• Sensitive: Light Sensitive
• BRN: 1732342
• CAS DataBase Reference: 1-CHLORO-5-IODOPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-5-IODOPENTANE(60274-60-4)
• EPA Substance Registry System: 1-CHLORO-5-IODOPENTANE(60274-60-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36-37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 60274-60-4(Hazardous Substances Data)

Usage

Uses

1-Chloro-5-iodopentane is used as a pharmaceutical intermediate.

InChI:InChI=1/C5H10ClI/c6-4-2-1-3-5-7/h1-5H2

Upstream product

• 111-29-5 1 ,5-pentanediol 
• 543-59-9 1-Chloropentane 
• 20395-28-2 5-chloropentyl acetate 
• 628-76-2 1,5-dichloropentane 
• 67-64-1 acetone 
• 928-50-7 5-chloropent-1-ene 
• 5259-98-3 5-chloropentan-1-ol 
• 74-85-1 ethene 
• 593-71-5 Chloroiodomethane 
• 821-09-0 n-Pent-4-enyl alcohol 
• 142-68-7 TETRAHYDROPYRANE 

Downstream Products

• 18804-36-9 chloro-1 heptyne-6 
• 22819-91-6 7-chloroheptanenitrile 
• 287-92-3 Cyclopentane 
• 129378-52-5 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide 
• 194597-84-7 (S)-5-Benzyl-2-(5-chloro-pentyl)-4-(4-methoxy-benzyl)-morpholin-3-one 
• 223927-72-8 1-chloro-5-(phenylselanyl)pentane 
• 56599-59-8 1-chloro-heptadec-6-yne 
• 411240-51-2 1-(5-chloro-pentyloxy)-4-(1,1-diallyl-but-3-enyl)-benzene 
• 411240-55-6 C₆₉H₈₉ClO₄ 
• 546141-51-9 tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate 
• 144028-22-8 1-(1-(methoxymethyl)ethenyl)-2-((trimethylsilyl)methylene)cyclohexane 
• 127016-38-0 triphenyl(7-(trimethylsilyl)-6-heptennyl)phosphonium iodide 
• 4728-90-9 spiro[5.6]dodecan-7-one 
• 1092980-36-3 1-benzyl-4-(5-chloropentyloxy)piperidine 

Relevant articles and documents

New 1-benzyl-4-hydroxypiperidine derivatives as non-imidazole histamine H3 receptor antagonists

A series of 1-benzyl-4-(3-aminopropyloxy)piperidine and 1-benzyl-4-(5-aminopentyloxy)piperidine derivatives has been prepared. The 1-benzyl-4-hydroxypiperidine derivatives obtained were evaluated for their affinities at recombinant human histamine H3 receptor, stably expressed in HEK 293T cells. All compounds investigated show moderate to pronounced in-vitro affinities. The most potent antagonists in this series 9b2 (hH3R, pKi = 7.09), 9b1 (hH3R, pKi = 6.78), 9b5 (hH3R, pKi = 6.99), and 9b6 (hH3R, pKi = 6.97) were also tested in vitro as H3 receptor antagonists - the electrically evoked contraction of the guinea-pig jejunum. The histaminergic H1 antagonism of selected compounds 9b1, 9b2, and 9b4-9b6 was established on the isolated guinea-pig ileum by conventional methods; the pA2 values were compared with the potency of pyrilamine. The compounds did not show any H1 antagonistic activity (pA 2 2 = 9.53).

A Mild and Convenient Procedure for Conversion of Alkenes into Alkyl Iodides via Reaction of Iodine Monochloride with Organoboranes

Alkenes are rapidly converted to alkyl iodides under mild conditions via a hydroboration-iodination sequence which utilizes iodine monochloride as the iodination agent.The iodination proceeds with inversion of configuration.A series of functionally substituted iodides was synthesized via the new products.