22825-14-5

Upstream product

• 6223-78-5 2,5-dichloro-2,5-dimethyl hexane 
• 95-48-7 ortho-cresol 
• 108-95-2 phenol 
• 110-03-2 2,5-dimethyl-2,5-hexanediol 
• 7446-70-0 aluminium trichloride 

Relevant academic research and scientific papers

NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression o￡ gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

Bi-aromatic compounds, pharmaceutical and cosmetic compositions containing same and uses

The invention relates to novel biaromatic compounds having general formula I and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for treating dermatological, rheumatic, respiratory, cardiovascular, and ophthalmological disorders, and for use in cosmetic compositions.

RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof

Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): wherein Ar is a radical having one of the formulae (a)-(e): which are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders are provided. In particular, based on their RXR-agonist activity, these compounds may be used to treat noninsulin-dependent diabetes mellitus (NIDDM) and obesity.

Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): STR1 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respirat

Polycyclic heterocyclic compounds, a process for their preparation and their use in human and veterinary medicine

A polycyclic heterocyclic compound has the formula STR1 wherein n is 1 or 2, R1 l represents (i) lower alkyl, (ii) --CH2 OH or (iii) STR2 R2 represents (a) hydrogen, (b) STR3 or (c)--OR3, R3 represents hydrogen, C1 -C20 alkyl mono or polyhydroxyalkyl, aryl or aralkyl optionally substituted, the residue of a sugar or STR4 wherein p is 1, 2, or 3, and r' and r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl optionally substituted, amino acid residue, aminated sugar residue, or together form a heterocycle, X represents oxygen, sulfur, SO, SO2 or --NR4, Y represents CR4 or a nitrogen atom and R4 represents hydrogen or lower alkyl. This polycyclic heterocyclic compound can be used in human and veterinary medicine and especially in the topical or systemic treatment of determatologic diseases.