228412-71-3

Basic information

• Product Name: β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate)
• Synonyms: [Methyl(2,3,4-tri-O-acetyl-β-D-glucopyranosyl)uronate]-4-nitro-phenyl Carbonate;β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate);UOZDLZHZVWFBBG-UHFFFAOYSA-N
• CAS NO: 228412-71-3
• Molecular Formula: C₂₀H₂₁NO₁₄
• Molecular Weight: 499.37904
• Product Categories: Glucuronides, Intermediates;Glucuronides;Intermediates
• Mol File: 228412-71-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate)(CAS DataBase Reference)
• NIST Chemistry Reference: β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate)(228412-71-3)
• EPA Substance Registry System: β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate)(228412-71-3)

Safety Data

• Hazardous Substances Data: 228412-71-3(Hazardous Substances Data)

Usage

Chemical Properties

β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate) is White Solid

Uses

Different sources of media describe the Uses of 228412-71-3 differently. You can refer to the following data:
1. p-Nitrophenyl Carbonate 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester is used in the synthesis of Varenicline Carbamoyl metabolite.
2. β-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Triacetate 1-(4-Nitrophenyl Carbonate) is used in the addition of protected Glucopyranuronic Acid.

Upstream product

• 3082-95-9 2,3,4-Tri-O-acetyl-β-D-glucopyranuronic acid methylester 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 5070-13-3 bis-(p-nitrophenyl) carbonate 
• 72692-06-9 methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate 
• 1033-26-7 4,4'-dinitrobenzophenone 
• 7355-18-2 (2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 
• 3080-47-5 methyl (benzyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid)uronate 

Relevant articles and documents

Mirabegron metabolite synthesis method

The invention discloses a mirabegron metabolite synthesis method and belongs to the field of drug metabolism. The mirabegron metabolite synthesis method can prepare a mirabegron metabolite from glucurolactone (1R)-2-2[2-(4-nitrophenyl)ethylamino]-1-phenylethanol as starting materials through eight-step reaction. The mirabegron metabolite synthesis method has the advantages that the synthesis method is reasonable in process design and strong in operability on the basis of optimal preparation steps and reaction conditions screened by a great number of experiments; the synthesis method is high inyield and can reach high chemical purity above 99% and therefore can be applied to industrial production of mirabegron metabolite; the mirabegron metabolite can provide a standard substance for metabolic mechanism research of the mirabegron drug, can be used for exploring the metabolic process of the drugs in vivo, and has high application research value in clinical pharmacokinetic study.

GLUCURONIDE PRODRUGS OF TOFACITINIB

The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I): (Formula (I)) where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.

Reagents for stereoselective preparation of N-carbamyl β-d- glucuronides

Carbamyl glucuronidation is an increasingly well-recognized route of metabolism for secondary amine drugs. Proper characterization of these metabolites requires the synthesis of authentic standards. O-Protected glucuronyl p-nitrophenyl carbonates can be p