228418-45-9

Basic information

• Product Name: Methyl 2-nitro-4-(trifluoromethyl)benzoate
• Synonyms: Benzoic acid, 2-nitro-4-(trifluoroMethyl)-, Methyl ester;4-(Methoxycarbonyl)-3-nitrobenzotrifluoride, Methyl 2-nitro-alpha,alpha,alpha-trifluoro-p-toluate
• CAS NO: 228418-45-9
• Molecular Formula: C₉H₆F₃NO₄
• Molecular Weight: 249.143
• Product Categories: Fluorine series
• Mol File: 228418-45-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 272℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.442
• Vapor Pressure: 0.0063mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl 2-nitro-4-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-nitro-4-(trifluoromethyl)benzoate(228418-45-9)
• EPA Substance Registry System: Methyl 2-nitro-4-(trifluoromethyl)benzoate(228418-45-9)

Safety Data

• Hazardous Substances Data: 228418-45-9(Hazardous Substances Data)

Usage

Uses

Methyl 2-Nitro-4-(trifluoromethyl)benzoate has been used in the synthesis of isoxazolinone antibacterial agents, using nitrogen as a replacement for the stereogenic center of the molecule. Also used in the preparation of benzo[b]azepines as inhibitors of cholesterol ester transfer.n

InChI:InChI=1/C9H6F3NO4/c1-17-8(14)6-3-2-5(9(10,11)12)4-7(6)13(15)16/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 349-03-1 1-bromo-4-trifluoromethyl-2-nitrobenzene 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 74-88-4 methyl iodide 
• 22227-55-0 2-nitro-4-trifluoromethyl benzamide 
• 320-94-5 2-nitro-4-trifluoromethylbenzoic acid 
• 1445-45-0 Trimethyl orthoacetate 

Downstream Products

• 192805-69-9 methyl 2-methylmercapto-4-(trifluoromethyl)benzoate 
• 61500-87-6 methyl 2-Amino-4-(trifluoromethyl)benzoate 
• 913299-79-3 methyl 2-(acetylamino)-3-nitro-4-(trifluoromethyl)benzoate 
• 913299-80-6 methyl 2-amino-3-nitro-4-(trifluoromethyl)benzoate 
• 913299-81-7 methyl 2,3-diamino-4-(trifluoromethyl)benzoate 
• 869550-68-5 methyl 2-(acetylamino)-4-(trifluoromethyl)benzoate 

Relevant articles and documents

Pyrazole derivative for FGFR inhibitor and preparation method of pyrazole derivative

The invention provides a pyrazole derivative for an FGFR inhibitor and a preparation method of the pyrazole derivative. The invention specifically relates to an amide pyrazole compound serving as an FGFR irreversible inhibitor, and a preparation method and application thereof. The present invention provides a compound as shown in Formula I, or a pharmaceutically acceptable salt, or solvate, isotope substitute, prodrug, or metabolite thereof. The compound as shown in general formula I have FGFR inhibitory activity, and is capable of preventing or treating disorders associated with FGFR activityor expression, preferably such as cancer.

Preparation method of methyl 2-nitryl-4-trifluoromethyl benzoate

The invention discloses a preparation method of methyl 2-nitryl-4-trifluoromethyl benzoate, belongs to the technical field of organic synthesis, and solves the technical problem that a new method forpreparing the methyl 2-nitryl-4-trifluoromethyl benzoate is provided. The method comprises the following steps: performing alkali catalytic or acid catalytic hydrolysis on 2-nitryl-4-trifluoromethyl benzonitrile to prepare 2-nitryl-4-trifluoromethyl phenyl methyl amide; mixing the 2-nitryl-4-trifluoromethyl phenyl methyl amide with a sulfuric acid-methanol solution and performing alcoholysis reaction to obtain the methyl 2-nitryl-4-trifluoromethyl benzoate. The method disclosed by the invention has the advantages of mild reaction conditions and simple post-processing; moreover, the high-puritymethyl 2-nitryl-4-trifluoromethyl benzoate can be obtained in a form of high yield, and realization of industrial production is facilitated.

Novel Heterocyclidene Acetamide Derivative

A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group,