22227-55-0

Basic information

• Product Name: 2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97
• Synonyms: 2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97
• CAS NO: 22227-55-0
• Molecular Formula: C₈H₅F₃N₂O₃
• Molecular Weight: 234.133
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 22227-55-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 167-170 °C(lit.)
• Boiling Point: 271.5°C at 760 mmHg
• Flash Point: 118°C
• Appearance: /
• Density: 1.525g/cm³
• Vapor Pressure: 0.00642mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97(22227-55-0)
• EPA Substance Registry System: 2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97(22227-55-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 22227-55-0(Hazardous Substances Data)

Usage

General Description

2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97 is a chemical compound with the molecular formula C8H5F3N2O3. It is a nitro-substituted benzamide with a trifluoromethyl group. 2-NITRO-4-TRIFLUOROMETHYLBENZAMIDE 97 is commonly used in the pharmaceutical and agrochemical industries for the synthesis of various organic compounds and as a building block for the development of pharmaceutical drugs and agricultural chemicals. It is also used as a reagent in chemical research and development. The purity of 97% indicates that it is a high-quality grade of the compound, suitable for use in a wide range of applications.

InChI:InChI=1/C8H5F3N2O3/c9-8(10,11)4-1-2-5(7(12)14)6(3-4)13(15)16/h1-3H,(H2,12,14)

Upstream product

• 778-94-9 2-nitro-4-trifluoromethyl-benzonitrile 

Downstream Products

• 228418-45-9 methyl 2-nitro-4-trifluoromethylbenzoate 
• 923945-95-3 2-nitro-4-trifluoromethyl-thiobenzamide 
• 713-41-7 2-amino-4-(trifluoromethyl)benzamide 

Relevant articles and documents

Preparation method of methyl 2-nitryl-4-trifluoromethyl benzoate

The invention discloses a preparation method of methyl 2-nitryl-4-trifluoromethyl benzoate, belongs to the technical field of organic synthesis, and solves the technical problem that a new method forpreparing the methyl 2-nitryl-4-trifluoromethyl benzoate is provided. The method comprises the following steps: performing alkali catalytic or acid catalytic hydrolysis on 2-nitryl-4-trifluoromethyl benzonitrile to prepare 2-nitryl-4-trifluoromethyl phenyl methyl amide; mixing the 2-nitryl-4-trifluoromethyl phenyl methyl amide with a sulfuric acid-methanol solution and performing alcoholysis reaction to obtain the methyl 2-nitryl-4-trifluoromethyl benzoate. The method disclosed by the invention has the advantages of mild reaction conditions and simple post-processing; moreover, the high-puritymethyl 2-nitryl-4-trifluoromethyl benzoate can be obtained in a form of high yield, and realization of industrial production is facilitated.

CAPSAICIN RECEPTOR AGONISTS

Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VRl activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.