22849-49-6

Basic information

• Product Name: H-GLY-ALA-LEU-OH
• Synonyms: GLYCYL-L-ALANYL-L-LEUCINE;H-GLY-ALA-LEU-OH;glycyl-alanyl-leucine
• CAS NO: 22849-49-6
• Molecular Formula: C₁₁H₂₁N₃O₄
• Molecular Weight: 259.3
• Mol File: 22849-49-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 566.1°C at 760 mmHg
• Flash Point: 296.1°C
• Appearance: /
• Density: 1.171
• Vapor Pressure: 2.7E-14mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: -15°C
• PKA: 3.36±0.10(Predicted)
• CAS DataBase Reference: H-GLY-ALA-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLY-ALA-LEU-OH(22849-49-6)
• EPA Substance Registry System: H-GLY-ALA-LEU-OH(22849-49-6)

Safety Data

• Hazardous Substances Data: 22849-49-6(Hazardous Substances Data)

Usage

General Description

H-GLY-ALA-LEU-OH is a peptide composed of four amino acids: glycine (Gly), alanine (Ala), leucine (Leu), and the C-terminal group (-OH). Glycine is the simplest amino acid with a hydrogen atom as its side chain, alanine has a methyl group, and leucine has a branched, aliphatic side chain. These amino acids are linked together through peptide bonds, forming a chain with a free hydroxyl group at the end. This chemical compound can be used in research, pharmaceuticals, and as a component in protein synthesis. Its specific sequence and structure may confer certain biochemical or biological properties, which can be further explored in various scientific studies.

InChI:InChI=1/C11H21N3O4/c1-6(2)4-8(11(17)18)14-10(16)7(3)13-9(15)5-12/h6-8H,4-5,12H2,1-3H3,(H,13,15)(H,14,16)(H,17,18)

Upstream product

• 61878-31-7 (S)-tert-butyl 2-((S)-2-aminopropanamido)-4-methylpentanoate 
• 21691-53-2 L-leucine tert-butyl ester 
• 60872-51-7 Boc-Gly-L-Ala-L-Leu-OtBu 
• 1738-69-8 L-Leucine benzyl ester 
• 3079-63-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionic acid 
• 61-90-5 L-leucine 
• 1999-42-4 D,L-alanyl-D,L-leucine 
• 27167-65-3 (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)-4-methylpentanoate 
• 42291-52-1 Boc-Gly-Ala-OH 
• 42538-67-0 caesium (2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoate 

Downstream Products

• 3303-34-2 L-alanyl-L-leucine 
• 671820-52-3 methyl 3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate 
• 1385775-76-7 N-Cbz-L-Phe-L-Cys-Gly-L-Ala-L-Leu-OH 

Relevant articles and documents

2,2'-Spirobi(1,3,2-benzodioxaphosphole): an Inexpensive and Effective Reagent for Peptide Synthesis

The readily accessible spirocyclic oxyphosphorane, 2,2'-spirobi(1,3,2-benzodioxaphosphole) (1), is a convenient and effective reagent for peptide coupling, racemisation as measured by the Izumiya test being strikingly suppressed 0.1percent in the presence of N-hydroxysuccinimide.

Effect of solvent on racemization in carbodiimide mediated solid phase fragment condensations

The Izumiya tripeptide was used to assess racemization in solid-phase fragment condensations. Boc-Gly-Ala-OH1 was coupled to Leu-PAM resin with DIC in a variety of solvents, both with and without HOBt. After cleavage from the resin, the extent of racemization was determined using C18 RP-HPLC to separate the epimers. Solvents used were DMF, NMP, TFE, and each of these as mixtures with DCM. Also tested was a mixture of NMP and DMSO (85:15). Couplings in FMD/DCM (1:1) and NMP/DCM (1:1) in the presence of HOBt were in excess of 98% and racemization was undetectable (0.1%).

Amino Acids and Peptides. XXX. Phosphorus in Organic Synthesis. XVII. Application of Diphenyl Phosphorazidate (DPPA) and Diethyl Phosphorocyanidate (DEPC) to Solid-phase Peptide Synthesis

Two coupling reagents for peptide synthesis, diphenyl phosphorazidate (DPPA) and diethyl phosphorocyanidate (DEPC), were tested using the solid-phase method.The reactivities of DPPA and DEPC were examined by coupling Boc-Ile with Gly-resin.In a comparison