228551-26-6

Upstream product

• 165806-85-9 4'-fluorophenyl-(tolylthio)methylisocyanide 
• 193747-11-4 2-propylthiopyrimidine-4-carboxaldehyde dimethyl acetal 
• 219729-65-4 2-(propylthio)pyrimidine-4-carboxaldehyde 
• 165806-95-1 1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene 

Downstream Products

• 228551-27-7 1-[(1-t-butoxycarbonyl)piperidin-4-yl]-4-(4-fluorophenyl)-5-[2-(2-propylsulfinyl)pyrimidin-4-yl]imidazole 

Relevant academic research and scientific papers

compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses

Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).

Phenoxypyrimidine inhibitors of p38α kinase: Synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles

As a continuation of our work with 1,4,5 substituted imidazole inhibitors of p38α, we report a series of 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl) imidazoles related to 7. The compounds have IC50's for inhibition of p38α ranging from 6.0 to 650 nM. Statistical analysis of the p38α inhibitor potencies shows a correlation of IC50's with the electron donating strength of low molecular weight substituents.