193747-11-4Relevant articles and documents
COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE
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Page/Page column 87, (2008/06/13)
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compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
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Example 23, (2010/11/29)
Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).
Phenoxypyrimidine inhibitors of p38α kinase: Synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles
Boehm, Jeffrey C.,Bower, Michael J.,Gallagher, Timothy F.,Kassis, Shouki,Johnson, Stephen R.,Adams, Jerry L.
, p. 1123 - 1126 (2007/10/03)
As a continuation of our work with 1,4,5 substituted imidazole inhibitors of p38α, we report a series of 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl) imidazoles related to 7. The compounds have IC50's for inhibition of p38α ranging from 6.0 to 650 nM. Statistical analysis of the p38α inhibitor potencies shows a correlation of IC50's with the electron donating strength of low molecular weight substituents.
