193747-11-4

Basic information

• Product Name: 4-DIMETHOXYMETHYL-2-PROPYLSULFANYL-PYRIMIDINE
• Synonyms: 4-DIMETHOXYMETHYL-2-PROPYLSULFANYL-PYRIMIDINE;4-(dimethoxymethyl)-2-(propylthio)Pyrimidine
• CAS NO: 193747-11-4
• Molecular Formula: C10H16N2O2S
• Molecular Weight: 228.31
• Mol File: 193747-11-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-DIMETHOXYMETHYL-2-PROPYLSULFANYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHOXYMETHYL-2-PROPYLSULFANYL-PYRIMIDINE(193747-11-4)
• EPA Substance Registry System: 4-DIMETHOXYMETHYL-2-PROPYLSULFANYL-PYRIMIDINE(193747-11-4)

Safety Data

• Hazardous Substances Data: 193747-11-4(Hazardous Substances Data)

Upstream product

• 67751-23-9 (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one 
• 106-94-5 propyl bromide 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 17356-08-0 thiourea 

Downstream Products

• 219729-65-4 2-(propylthio)pyrimidine-4-carboxaldehyde 
• 193746-84-8 4-(dimethoxymethyl)-2-methoxypyrimidine 
• 228551-26-6 1-[(1-t-butoxycarbonyl)piperidin-4-yl]-4-(4-fluorophenyl)-5-[2-(2-propylthio)pyrimidin-4-yl]imidazole 

Relevant articles and documents

Novel substituted imidazole compounds

Novel 1,4,5 substituted imidazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses

Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).

Substituted imidazole compounds

The present invention relates to novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as CSBP/p38 inhibitors.

Cycloalkyl substituted imidazoles

Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy.

Phenoxypyrimidine inhibitors of p38α kinase: Synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles

As a continuation of our work with 1,4,5 substituted imidazole inhibitors of p38α, we report a series of 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl) imidazoles related to 7. The compounds have IC50's for inhibition of p38α ranging from 6.0 to 650 nM. Statistical analysis of the p38α inhibitor potencies shows a correlation of IC50's with the electron donating strength of low molecular weight substituents.

Substituted imidazole compounds

Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.