22863-60-1Relevant academic research and scientific papers
Asymmetric Synthesis of 3,3′-Piperidinoyl Spirooxindoles and Discovery of Stereospecific Cycloadducts as Novel Hedgehog Pathway Modulators
Flegel, Jana,Heitkamp, Franziska,Kumar, Kamal,Otte, Felix,Pergomet, Jorgelina L.,Rehan, Mohammad,Strohmann, Carsten
supporting information, p. 3140 - 3152 (2020/09/07)
An enantioselective hetero-Diels-Alder reaction of alkylidene oxindoles and 2-aza-3-silyloxy-1,3-butadienes, catalyzed by divalent transition metal complexes with N, N ′-dioxide ligands offered an efficient access to natural-product-based 3,3′-piperidinoyl spirooxindole class of small molecules. exo -Cycloadducts formed via stereospecific cycloaddition with Z -olefin displayed potent activity in modulation of hedgehog pathway.
In?vitro targeting of colon cancer cells using spiropyrazoline oxindoles
Nunes, Rute C.,Ribeiro, Carlos J.A.,Monteiro, ?ngelo,Rodrigues, Cecília M.P.,Amaral, Joana D.,Santos, Maria M.M.
, p. 168 - 179 (2017/08/10)
We report on the synthesis and biological evaluation of a library of twenty-three spiropyrazoline oxindoles. The antiproliferative activity of the chemical library was evaluated in HCT-116 p53(+/+) human colon cancer cell line with eight deriva
Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines
Monteiro, ?ngelo,Gon?alves, Lídia M.,Santos, Maria M.M.
, p. 266 - 272 (2014/05/06)
A series of novel spiropyrazoline oxindole derivatives was synthesized by 1,3-dipolar cycloaddition reaction. The compounds were screened for their in vitro cytotoxic activity against MCF-7 breast cancer cell line (estrogen receptor positive (ER+) and hum
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers
Zhu, Gui-Dong,Gandhi, Viraj B.,Gong, Jianchun,Luo, Yan,Liu, Xuesong,Shi, Yan,Guan, Ran,Magnone, Shayna R.,Klinghofer, Vered,Johnson, Eric F.,Bouska, Jennifer,Shoemaker, Alexander,Oleksijew, Anatol,Jarvis, Ken,Park, Chang,Jong, Ron De,Oltersdorf, Tilman,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 3424 - 3429 (2007/10/03)
We describe a series of potent and selective oxindole-pyridine-based protein kinase B/Akt inhibitors. The most potent compound 11n in this series demonstrated an IC50 of 0.17 nM against Akt1 and more than 100-fold selectivity over other Akt iso
