22876-96-6

Upstream product

• 40649-75-0 2'-Hydroxy-4-methoxy-3',4'-benzochalkone 
• 711-79-5 1-hydroxy-2-acetonaphthone 
• 123-11-5 4-methoxy-benzaldehyde 
• 125574-12-1 (E)-1-(1-hydroxynaphthalen-2-yl)-3-(4-methoxyphenyl)prop-2-en-1-one 

Downstream Products

• 129457-20-1 cobalt(II){3-(1-hydroxy-2-naphthyl)-5-(4-MeO-phenyl)pyrazoline}2 dihydrate 
• 129457-27-8 nickel(II){3-(1-hydroxy-2-naphthyl)-5-(4-MeO-phenyl)pyrazoline}2 dihydrate 
• 129457-18-7 nickel(II){3-(1-hydroxy-2-naphthyl)-5-(4-MeO-phenyl)pyrazoline}2 * 2pyridine 
• 129457-23-4 cobalt(II){3-(1-hydroxy-2-naphthyl)-5-(4-MeO-phenyl)pyrazoline}2 * 2pyridine 
• 129457-15-4 nickel(II){3-(1-hydroxy-2-naphthyl)-5-(4-MeO-phenyl)pyrazoline}2 
• 1446419-69-7 3-(1-hydroxynaphthalen-2-yl)-5-bis(4-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-64-2 3-(1-hydroxynaphthalen-2-yl)-5-(4-methoxyphenyl)-N-phenyl-2-pyrazoline-1-carbothioamide 
• 1446419-65-3 3-(1-hydroxynaphthalen-2-yl)-N-(2-methoxyphenyl)-5-(4-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-66-4 3-(1-hydroxynaphthalen-2-yl)-N-(3-methoxyphenyl)-5-(4-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-67-5 3-(1-hydroxynaphthalen-2-yl)-N,5-bis(4-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-68-6 N-(2,4-dimethoxyphenyl)-3-(1-hydroxynaphthalen-2-yl)-5-(4-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 129457-28-9 copper(II){3-(1-hydroxy-2-naphthyl)-5-(4-MeO-phenyl)pyrazoline}2 

Relevant academic research and scientific papers

ANTICANCER COMPOSITION INCLUDING THE PYRAZOLINE-CARBOTHIOAMIDE COMPOUNDS

The present invention relates to a novel pyrazoline-carbothioamide-based compound and a composition including the compound as an active ingredient and, more specifically, to a pyrazoline-carbothioamide-based compound which is represented by general formula 1 and has inhibitory activity of cancer cell growth by reducing aurora kinase activity, or a composition including a pharmaceutically acceptable salt thereof for preventing and treating cancer diseases, thereby having effects capable of being helpfully used in preventing and treating cancer diseases.

A novel benzochalcones and composition for anticancer comprising the same

The present invention refers to same derivatives and including novel benzo knife cone is directed to anticancer composition.

1H and 13C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups

Chalcones are known to act on various physiological targets. As a result, structural modifications of chalcones have been studied extensively. Benzochalcones, in which the A-ring of chalcone is substituted with a naphthalene unit, inhibits breast cancer resistance protein. Chalcones in which the α,β-unsaturated carbonyl group is switched with a pyrazoline moiety are potent cytotoxic agents against various cancer cell lines, and chalcones with a pyrazoline-1-carbothioamide group instead of an α,β-unsaturated carbonyl group exhibit antimicrobial activities. The present report describes hybrid molecules designed from benzochalcone and pyrazoline-carbothioamide. Methoxylation of plant-derived polyphenols alters their hydrophobicity, resulting in changes in biological function and intracellular compartmentation. In the current study, 22 novel methoxylated 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide derivatives were prepared. This report provides complete assignments of their 1H and 13C NMR data, which can be used to subsequently identify chalcones bearing pyrazoline-carbothioamide groups. Copyright

Complete assignments of 1H and 13C NMR data for 21 naphthalenyl-phenyl-pyrazoline derivatives

To find potent new chemotherapy drugs, we designed and synthesized a series of naphthochalcones bearing naphthalenyl-phenyl-pyrazoline moieties. The complete 1H and 13C NMR data for these compounds are reported here and can be used t