22876-96-6Relevant articles and documents
ANTICANCER COMPOSITION INCLUDING THE PYRAZOLINE-CARBOTHIOAMIDE COMPOUNDS
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Paragraph 0038; 0039, (2017/01/26)
The present invention relates to a novel pyrazoline-carbothioamide-based compound and a composition including the compound as an active ingredient and, more specifically, to a pyrazoline-carbothioamide-based compound which is represented by general formula 1 and has inhibitory activity of cancer cell growth by reducing aurora kinase activity, or a composition including a pharmaceutically acceptable salt thereof for preventing and treating cancer diseases, thereby having effects capable of being helpfully used in preventing and treating cancer diseases.
1H and 13C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups
Yoon, Hyuk,Ahn, Seunghyun,Park, Mijoo,Kim, Dong-Wook,Kim, Sang Ho,Koh, Dongsoo,Lim, Yoongho
, p. 500 - 508 (2013/07/26)
Chalcones are known to act on various physiological targets. As a result, structural modifications of chalcones have been studied extensively. Benzochalcones, in which the A-ring of chalcone is substituted with a naphthalene unit, inhibits breast cancer resistance protein. Chalcones in which the α,β-unsaturated carbonyl group is switched with a pyrazoline moiety are potent cytotoxic agents against various cancer cell lines, and chalcones with a pyrazoline-1-carbothioamide group instead of an α,β-unsaturated carbonyl group exhibit antimicrobial activities. The present report describes hybrid molecules designed from benzochalcone and pyrazoline-carbothioamide. Methoxylation of plant-derived polyphenols alters their hydrophobicity, resulting in changes in biological function and intracellular compartmentation. In the current study, 22 novel methoxylated 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide derivatives were prepared. This report provides complete assignments of their 1H and 13C NMR data, which can be used to subsequently identify chalcones bearing pyrazoline-carbothioamide groups. Copyright