22883-27-8Relevant academic research and scientific papers
A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions
Xue, Kangsheng,Sun, Guoxiang,Zhang, Yanzhi,Chen, Xubing,Zhou, Yang,Hou, Jinjun,Long, Huali,Zhang, Zijia,Lei, Min,Wu, Wanying
, p. 625 - 634 (2021)
A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.
Synthesis, Characterisation, Molecular Docking, Anti-microbial and Anti-diabetic Screening of Substituted 4-indolylphenyl-6-arylpyrimidine-2-imine Derivatives
Ramya, Veerasamy,Vembu, Santhirakasu,Ariharasivakumar, Ganesan,Gopalakrishnan, Manathusamy
, p. 515 - 526 (2017)
The purpose of the research is to synthesise a novel series of (E)-2-(4-(1H-indol-3-yl)-6-p-substituted phenylpyrimidin-2-yl)dimethylguanidine derivatives since 3-(1H-indol-3-yl)-1-p-substituted phenylprop-2-en-1-one and evaluate their molecular docking s
Synthesis, docking, and evaluation of novel thiazoles for potent antidiabetic activity
Sravanthi,Sajitha Lulu,Vino,Jayasri,Mohanapriya,Manju
, p. 1306 - 1315 (2017)
In this study, a series of novel substituted pyrazoles containing indole and thiazole motifs were synthesized and evaluated for their antihyperglycemic activity against α-amylase and α-glucosidase enzymes. Among them, 2-(5-(1H-indol-3-yl)-3-phenyl-1H-pyra
Synthesis and antioxidant activity of a new class of pyrazolyl indoles, thiazolyl pyrazolyl indoles
Ummadi, Nagarjuna,Gundala, Sravya,Venkatapuram, Padmavathi,Adivireddy, Padmaja
, p. 1574 - 1584 (2017)
A new class of bis and tris heterocycles–pyrazolyl indoles and thiazolyl pyrazolyl indoles were prepared from the Michael acceptor (E)-3-(1H-indol-3-yl)-1-arylprop-2-en-1-ones by ultrasound irradiation technique and tested for antioxidant activity. The th
Synthesis and evaluation of chalcone derivatives as novel sunscreen agent
Jumina, Jumina,Lee, Wonkoo,Swasono, Respati Tri,Wijayanti, Lucia Wiwid
, (2021/05/26)
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region. Therefore, in
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids
Angeli, Andrea,Arifuddin, Mohammed,Purnachander Yadav, P.,Sigalapalli, Dilep Kumar,Singh, Priti,Supuran, Claudiu T.,Swain, Baijayantimala,Thacker, Pavitra S.
, (2020/04/15)
Sulfonamide is one of the most promising classes of classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1,2,3-triazole (6a-q) has been synthesized by click chemistry reaction and in
Alpha,beta-unsaturated ketone derivatives, preparation method of derivatives and application of derivatives as medicines
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Paragraph 0135-0137, (2019/12/15)
The invention relates to the technical field of medicine, and proposes alpha,beta-unsaturated ketone derivatives and a preparation method thereof. The derivatives have a structural general formula represented by a formula I shown in the specification, whe
Preheated fly-ash catalyzed aldol condensation: Efficient synthesis of chalcones and antimicrobial activities of some 3-thienyl chalcones
Arulkumaran, Ranganathan,Vijayakumar, Sambandhamoorthy,Sakthinathan, S. Pazhanivel,Kamalakkannan, Dakshnamoorthy,Ranganathan, Kaliyaperumal,Suresh, Ramamoorthy,Sundararajan, Rajasekaran,Vanangamudi, Ganesan,Thirunarayanan, Ganesamoorthy
, p. 1684 - 1690 (2013/09/24)
In the present study we have prepared a series of some chalcones using solvent - free Aldol - condensation by microwave irradiation. The yields of the ketones are more than 60%. The synthesised chalcones were characterized by their analytical, physical and spectral data. The antimicrobial activities of substituted styryl 3-thienyl ketones have been studied using Bauer-Kirby method.
An efficient method for the synthesis of isoxazolines under microwave irradiation and solvent-free conditions
Patil, Pravin O.,Bari, Sanjay B.
, p. 3588 - 3590 (2013/04/24)
A facile method for the synthesis of new isoxazoline derivatives are being reported starting from substituted 1-(1H-indol-3-yl)-3-(substituted aryl)-prop-1-en-3-ones and hydroxylamine hydrochloride under solvent free conditions and microwave irradiation.
Csp2-Csp2 bond formation via Lewis acid/ammonium salt cocatalyzed tandem addition and oxidative dehydrogenation strategy: Alkenylation of indoles with α,β-unsaturated ketones
Xiang, Shi-Kai,Wu, Guolin,Zhang, Bo,Cui, Yuxin,Jiao, Ning
supporting information; experimental part, p. 3802 - 3804 (2012/09/21)
The alkenylation of indoles with α,β-unsaturated ketones through a tandem addition and oxidative dehydrogenation strategy has been developed. This method provides an alternative approach for C3 alkenylation of indoles with α,β-unsaturated ketones. Using inexpensive and readily available BF3·Et2O and an ammonium salt as the efficient cocatalyst constitutes the attractive advantage of this reaction.
