30030-96-7

Upstream product

• 4971-56-6 tetrahydrofuran-2,4-dione 
• 100-52-7 benzaldehyde 
• 108-30-5 succinic acid anhydride 

Downstream Products

• 87192-17-4 10-Phenyl-4,10-dihydro-1H,3H-furo<3,4-c><1,5>benzothiazepin-1-one 
• 87192-08-3 4-(Phenylmethylene)-2,4-dihydro-5-(hydroxymethyl)-2-methyl-3H-pyrazol-3-one 
• 135005-10-6 3-(1',2'-diphenylethyl)-4-hydroxy-2(5H)-furanone 
• 87192-03-8 4-(Phenylmethylene)-2,4-dihydro-5-(hydroxymethyl)-3H-pyrazol-3-one 
• 1138661-91-2 8,11-dihydro-11-phenylbenzo[f]furo[3,4-b]quinolin-10(7H)-one 
• 22884-81-7 3-benzyltetrahydrofuran-2,4-dione 
• 3734-22-3 3-benzyl-4-hydroxy-5H-furan-2-one 
• 1227691-85-1 4-benzylidene-3-(phenylthiomethyl)-1H-pyrazol-5(4H)-one 
• 1227692-18-3 4-benzylidene-3-(bromomethyl)-1H-pyrazol-5(4H)-one 

Relevant academic research and scientific papers

Entrapment in micellar assemblies switches the excimer population of potential therapeutic luminophore azapodophyllotoxin

Azapodophyllotoxin is a new class of anti-tumor agent with brilliant therapeutic activity and understanding its physicochemical nature in bio-mimetic microenvironments may provide substantial importance in context of its intercellular localization, efficacy as well as delivery. The present work epitomizes environment-sensitive fluorescence modulation of a prodigy, 4-(2-Hydroxyethyl)-10-phenyl-3,4,6,7,8,10- hexahydro-1H-cyclopenta[g]furo[3,4-b]quinoline-1-one (HPFQ) from the class of anti-cancer agent Azapodophyllotoxin, in differently charged model bio-mimetic micellar microenvironment of cationic CTAB, anionic SDS and neutral Triton X-100 using UV–visible absorption, steady state fluorescence, time-resolved fluorescence and fluorescence anisotropy studies. As a distinct phenomenon, anticancer HPFQ exhibits prolific fluorescence in solvents of varying polarity, originating from a mixed contribution of locally excited, charge transfer and excimer emission. A dramatic modulation in the photophysics of HPFQ has been observed in two types of surfactant consortiums: pre-micellar and post-micellar at physiological and anoxic pH. On photo-excitation, anti-cancer HPFQ exists in monomer-excimer equilibrium with varying ratios in different polarity regions. The marked enhancement in fluorescence intensity of HPFQ in post-micellar region of the surfactant under study probably arises due to regeneration of the monomer from its excimer. This reoccurrence reduces the possibility of F?rster resonance energy transfer (FRET) from monomer to excimer, which essentially increases the desired emission intensity. Localization of HPFQ in micellar systems highly depends on polarity gradient inside the micelle, electrostatic, hydrophobic and intermolecular hydrogen bonding interactions. Further corroboration with the polarity sensitive experiments in dioxane-water mixture indicates towards spatial localization of the probe molecule in the stern layer of cationic CTAB, sheer surface of neutral TX100 and outer Gouy-Chapman layer in anionic SDS micelles. A molecular binary logic gate correlates the dominance of micellization over the polarity factor, which enhances the fluorescence response of HPFQ. The enhancement of the emissive potential of anti-cancer HPFQ in biomimetic environments by switching its excimer population may have an immense importance to achieve the status of a dual therapeutic and imaging agent altogether in progressive biomedical research.

Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors

Iridoids comprise a large group of monoterpenoid natural products displaying a diverse array of biological activities ranging from neurotrophic to anti-inflammatory and anti-tumorigenic properties. Therefore, the development of concise synthesis routes to compound collections inspired by the structural features of these natural products is of particular relevance for chemical biology and medicinal chemistry. Herein we describe a samarium diiodide-mediated synthesis of a small, focused iridoid-inspired compound collection. Characterization of these iridoid analogues in biological assays revealed novel small-molecule inhibitors of autophagy.

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assa

TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.

Tetronic acid in reaction with aromatic aldehydes and 2-naphthylamine. Investigation of fluorescent and nonlinear-optical characteristics of compounds obtained

By Knoevenagel condensation and by three-component condensation 3-arylmethylenetetrahydrofuran-2,4-diones and previously unknown 8,11-dihydro-11-arylbenzo[f]furo[3,4-b]quinolin-10(7H)-ones were respectively synthesized. The luminescent spectra and nonline