2290-89-3

Basic information

• Product Name: Benzenemethanamine,N-phenyl-, hydrochloride (1:1)
• Synonyms: Benzenemethanamine,N-phenyl-, hydrochloride (9CI); Benzylamine, N-phenyl-, hydrochloride (8CI); N-Benzylaniline hydrochloride; N-Benzylanilinium chloride
• CAS NO: 2290-89-3
• Molecular Formula: C₁₃H₁₃N*ClH
• Molecular Weight: 246.391
• Mol File: 2290-89-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 349.5°Cat760mmHg
• Flash Point: 192.6°C
• Density: 1.17g/cm³
• CAS DataBase Reference: Benzenemethanamine,N-phenyl-, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine,N-phenyl-, hydrochloride (1:1)(2290-89-3)
• EPA Substance Registry System: Benzenemethanamine,N-phenyl-, hydrochloride (1:1)(2290-89-3)

Safety Data

• Hazardous Substances Data: 2290-89-3(Hazardous Substances Data)

Usage

Structure

It is a hydrochloride salt of N-phenylbenzenemethanamine.

Derivative of

Amphetamine

Uses

Organic Synthesis: Used as a reagent in organic synthesis.
Precursor: Serves as a precursor to other chemicals.
Pharmaceutical Production: Utilized in the production of pharmaceuticals.
Illicit Drug Production: Employed in the production of illicit drugs.

Properties

Stimulant: Exhibits stimulant properties.
Psychoactive: Displays psychoactive properties.

Safety Precautions

Toxicity: Can be toxic if mishandled.
Hazardous: Should be handled with caution.

Upstream product

• 3768-55-6 N-trimethylsilylaniline 
• 100-39-0 benzyl bromide 
• 758640-21-0 N-Benzylaniline 
• 1426958-04-4 4,4,5,5-tetramethyl-N-phenyl-N-(phenylmethyl)-1,3,2-dioxaborolan-2-amine 
• 93-98-1 N-phenyl benzoyl amide 
• 62-53-3 aniline 
• 100-51-6 benzyl alcohol 
• 538-51-2 benzylidene phenylamine 
• 83837-64-3 phenyl(chloro)(OMe)borane 
• 622-79-7 benzyl azide 
• 873-51-8 phenylborondichloride 

Downstream Products

• 66711-48-6 N-benzyl-N'-methyl-N-phenylethylenediamine 
• 53446-51-8 N-phenyl-N-benzylthiourea 
• 620948-93-8 vabicaserin 
• 65948-22-3 3-benzylbenzo[d]thiazol-2(3H)-imine 

Relevant articles and documents

Hydroborative reduction of amides to amines mediated by La(CH2C6H4NMe2-: O)3

The deoxygenative reduction of amides to amines is a great challenge for resonance-stabilized carboxamide moieties, although this synthetic strategy is an attractive approach to access the corresponding amines. La(CH2C6H4NMe2-o)3, a simple and easily accessible lanthanide complex, was found to be highly efficient not only for secondary and tertiary amide reduction, but also for the most challenging primary reduction with pinacolborane. This protocol exhibited good tolerance for many functional groups and heteroatoms, and could be applied to gram-scale synthesis. The active species in this catalytic cycle was likely a lanthanide hydride.

Lithium compound catalyzed deoxygenative hydroboration of primary, secondary and tertiary amides

A selective and efficient route for the deoxygenative reduction of primary to tertiary amides to corresponding amines has been achieved with pinacolborane (HBpin) using simple and readily accessible 2,6-di-tert-butyl phenolate lithium·THF (1a) as a catalyst. Both experimental and DFT studies provide mechanistic insight. This journal is

In water alkylation of amines with alcohols through a borrowing hydrogen process catalysed by ruthenium nanoparticles

A simple and environmentally benign procedure for the synthesis of secondary amines in water has been developed. Combining Ru3(CO)12, tetraphenylcyclopentadienone and a small quantity of TGPS-750-M surfactant, primary and secondary alcohols were alkylated at N employing equimolar amounts of aromatic amines in water. The reaction occurs under microwave (MW) dielectric heating with high conversion and high yield. When required, the use of biomass-derived 2-MeTHF or GVL as a co-solvent is possible. Under the influence of MWs, a Ru nanoparticle-nanomicelle combination was formed acting as an effective and recyclable catalyst. This protocol was also employed for "in water" cyclisation to synthesise biologically relevant pyrrolobenzodiazepines (PBDs).