229006-58-0

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 144464-65-3 7-Trifluoromethanesulphonyloxy-1,2,3,4-tetrahydronaphthalen-1-one 
• 106-38-7 para-bromotoluene 
• 24037-79-4 bicyclo<4.4.0>dec-10-en-2-one 
• 624-31-7 4-tolyl iodide 
• 930-68-7 cyclohexenone 
• 22009-38-7 7-hydroxy-1-tetralone 
• 6836-19-7 7-Methoxy-1-tetralone 
• 75506-74-0 3-<3-(1,3-dioxolan-2-yl)propyl>cyclohexanone 

Downstream Products

• 724767-18-4 3-(4-methylphenyl)-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-one 
• 229006-60-4 7-(4-methyl-phenyl)-3,4-dihydronaphthalene-2-carboxylic acid 
• 229003-49-0 7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide 
• 724767-19-5 2-(4-methylphenyl)-6,7-dihydro-5H-benzo[a][7]annulen-8-yl trifluoromethanesulfonate 

Relevant academic research and scientific papers

A novel palladium-catalyzed arylation - dehydroaromatization reaction: Synthesis of 7-aryltetralones

(Chemical Equation Presented) A new one-pot room-temperature palladium-catalyzed synthesis of 7-aryltetralones was discovered. This tandem process includes a palladium-catalyzed γ-selective arylation of the enone 4 followed by a dehydrogenation-aromatization of the initial cross-coupling product.

A ring expansion strategy in antiviral synthesis: A novel approach to TAK-779

A synthesis of TAK-779 that relies on construction of a key carboxylic acid intermediate by a ring expansion with TMSCHN2 is described.

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

The search for new small-molecule CCR5 antagonists by high-throughput screening (HTS) of the Takeda chemical library using [125I]RANTES and CHO/CCR5 cells led to the discovery of lead compounds (A, B) with a quaternary ammonium or phosphonium m

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.