229027-67-2Relevant academic research and scientific papers
Synthesis of DNA-(3')-PNA chimeras with conformationally restricted linkers based on 4-hydroxyproline
Verheijen, Jeroen C.,Van Roon, Anne-Marie M.,Van Der Laan, Alexander C.,Van Der Marel, Gijsbert A.,Van Boom, Jacques H.
, p. 493 - 508 (2007/10/03)
The synthesis and evaluation of DNA-(3')-PNA chimeras containing rigid linkers based on (R/S)-4-hydroxy-D/L-proline are described. It is shown that installment of the trans-L-linker using the tetrabutylammonium salt of (R)- 4-(4,4'-dimethoxytrityloxy)-N-(thymin-l-yl)acetyl-L-proline (2) leads to a DNA-(3')-PNA chimera which hybridizes efficiently with complementary RNA.
