22908-30-1Relevant academic research and scientific papers
NOVEL PIPERIDINE DERIVATIVES
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Page/Page column 70, (2016/06/28)
The invention relates to a compound of formula (I) wherein A1, A2 and R1to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
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Page/Page column 215-216, (2011/10/05)
The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
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Page/Page column 102, (2010/06/11)
The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
Practical syntheses of oxindole derivatives: Chemical development towards 2-(5-chloro-2-oxo-2,3-dihydroindol-1-yl)acetamide and (S)-2-(5-Chloro-2-oxo-2,3- dihydroindol-1-yl)propionamide
Broeders, Fabienne,Defrere, Laurent,Deltent, Marie-France,Driessens, Frank,Gilson, Frederic,Grooters, Luc,Ikonomakos, Xavier,Limauge, Frederic,Sergeef, Emmanuel,Verstraeten, Natacha
experimental part, p. 442 - 449 (2010/04/22)
We describe development of scalable syntheses of novel oxindole-type SV2A ligands with improved potency towards seizure suppression.
Method for treating allergies using substituted pyrazoles
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, (2008/06/13)
A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
Oxidative nucleophilic substitution of hydrogen in nitroarenes by silyl enol ethers
Ma?kosza, Mieczys?aw,Surowiec, Marek
, p. 6261 - 6266 (2007/10/03)
Enolates generated by treatment of silyl ketene acetals and enol ethers with fluoride ion sources add to nitroarenes to produce σH adducts that oxidize either with KMnO4 to give substituted nitroarenes or with dimethyldioxirane to give substituted phenols. In the latter case the oxidation results in replacement of the nitro group with a hydroxy group. It was shown that high effectiveness of these reactions is not due to stabilization of the σH adducts via O-silylation but due to the nature of the accompanying cation.
A Simple and Efficient Synthesis of Alkyl (2-Nitroaryl)acetates and Alkyl 2-(2-Nitroaryl)propanoates via Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes by Carbanions or Alkyl Chloroacetates of Alkyl 2-Chloropropanoates
Mudryk, B.,Makosza, M.
, p. 1007 - 1009 (2007/10/02)
Alkyl chloroacetates react with nitroarenes and potassium tert-butoxide in dimethylformamide according to the Vicarious Nucleophilic Substitution pattern, preferentially in the position ortho to the nitro group, giving alkyl (2-nitroaryl)acetates in usually good yields.Alkyl 2-(2-nitroaryl)propanoates are obtained in an analogous manner.
