22912-25-0

Basic information

• Product Name: 1-(1-Cyanocyclohexyl)pyrrolidine
• Synonyms: 1-(1-Cyanocyclohexyl)pyrrolidine;1-(1-Pyrrolidinyl)cyclohexanecarbonitrile
• CAS NO: 22912-25-0
• Molecular Formula: C₁₁H₁₈N₂
• Molecular Weight: 178.274
• Mol File: 22912-25-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 291.3°Cat760mmHg
• Flash Point: 119.2°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 1-(1-Cyanocyclohexyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Cyanocyclohexyl)pyrrolidine(22912-25-0)
• EPA Substance Registry System: 1-(1-Cyanocyclohexyl)pyrrolidine(22912-25-0)

Safety Data

• Hazardous Substances Data: 22912-25-0(Hazardous Substances Data)

Usage

Type of compound

Pyrrolidine derivative

Functional groups

Cyano group and cyclohexyl ring

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Biological activity

Potential applications in medicinal chemistry research

Molecular weight

192.3 g/mol

Physical state

White to off-white solid

Versatility

Diverse uses and potential biological significance

InChI:InChI=1/C11H18N2/c12-10-11(6-2-1-3-7-11)13-8-4-5-9-13/h1-9H2

Upstream product

• 123-75-1 pyrrolidine 
• 151-50-8 potassium cyanide 
• 108-94-1 cyclohexanone 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 143-33-9 sodium cyanide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 14228-29-6 1-pyrrolidin-1-yl-1-vinylcyclohexane 
• 41907-01-1 1-pyrrolidin-1-yl-cyclohexanecarboxylic acid amide 
• 39627-14-0 (2-cyclohexylideneethyl)benzene 
• 2129-93-3 n-propylidenecyclohexane 
• 21623-78-9 1-methyl-1-vinylcyclohexane 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 

Relevant articles and documents

Syntheses of fluorinated phencyclidine analogs

Syntheses of several fluorinated phencyclidine (PCP) analogs are described. These compounds are being used to probe PCP binding sites on N-methyl-D-aspartate (NMDA) receptors. The compounds were prepared in good yields by Grignard reaction of appropriate fluorine substituted bromobenzene with carbonitrile intermediates. Syntheses of the known compound 1-[1-(3-fluorophenyl) cyclohexyl]piperidine, and the novel compounds 1-[1-(4-fluorophenyl)cyclohexyl]piperidine, 1-[1-(3-fluorophenyl) cyclohexyl]pyrrolidine, and 1-[1-(4-fluorophenyl)cyclohexyl]pyrrolidine are reported.

Heterogeneously catalysed Strecker-type reactions using supported Co(ii) catalysts: Microwave vs. conventional heating

A range of α-aminonitriles could be efficiently prepared from various aldehydes/ketones and primary or secondary amines using a highly active and stable Co(ii) complex supported on different mesoporous supports at both room temperature and low temperature microwave irradiation under solventless conditions. Catalysts were also highly reusable under the investigated reaction conditions and could be reused at least 10 times without loss of catalytic activity. The Royal Society of Chemistry.

Phencyclidine analogs for immunoassay

Novel analogs of phencyclidine (PCP) are disclosed. The analogs are capable of reacting with anti-PCT antibodies and are useful in immunoassays. The following analogs are described: STR1 wherein wherein X is --OH or a reporter molecule selected from the group consisting of aminofluorescein and aminomethylfluorescein and n is an integer between 1 and 10, inclusive.