229180-32-9Relevant academic research and scientific papers
Phase-transfer-catalyzed asymmetric Darzens reaction
Arai, Shigeru,Shirai, Yoshiki,Ishida, Toshimasa,Shioiri, Takayuki
, p. 6375 - 6386 (1999)
Catalytic asymmetric Darzens reaction promoted by a chiral phase- transfer catalyst derived from cinchonine is described. The desired α,β- epoxy ketones were obtained by use of α-chloro acyclic and cyclic ketones as substrates with moderate to high enantiomeric excesses under mild reaction conditions. This methodology can be quite an effective protocol for practical asymmetric synthesis.
