anti-2-chloro-3-hydroxy-4-methylpentanophenone

Base Information

• Chemical Name: anti-2-chloro-3-hydroxy-4-methylpentanophenone
• CAS No.: 229180-32-9
• Molecular Formula: C₁₂H₁₅ClO₂
• Molecular Weight: 226.703
• Mol file: 229180-32-9.mol

Synonyms:anti-2-chloro-3-hydroxy-4-methylpentanophenone

Chemical Property of anti-2-chloro-3-hydroxy-4-methylpentanophenone

Chemical Property:

Purity/Quality:

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Technology Process of anti-2-chloro-3-hydroxy-4-methylpentanophenone

There total 3 articles about anti-2-chloro-3-hydroxy-4-methylpentanophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + isobutyraldehyde (78-84-2) → anti-2-chloro-3-hydroxy-4-methylpentanophenone + anti-2-chloro-3-hydroxy-4-methylpentanophenone (229180-32-9) + 2-chloro-3-hydroxy-4-methyl-1-phenylpentan-1-one

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 2h; Yield given; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(99)00213-6

Reference yield: 30.0%

2-chloro-3-hydroxy-4-methyl-1-phenylpentan-1-one → 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + trans-(2S,3R)-epoxy-4-methyl-1-phenylpentan-1-one (187742-13-8) + ((2R,3S)-3-isopropyloxiran-2-yl)(phenyl)methanone + anti-2-chloro-3-hydroxy-4-methylpentanophenone + anti-2-chloro-3-hydroxy-4-methylpentanophenone (229180-32-9)

Guidance literature:

With lithium hydroxide; N-[4-(trifluoromethyl)benzyl]cinchoninium bromide; In dibutyl ether; at 4 ℃; for 40h; Product distribution; transformation α-chloro-β-hydroxyketones to epoxides;

DOI:10.1016/S0040-4020(99)00213-6

Reference yield:

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + isobutyraldehyde (78-84-2) → trans-(2S,3R)-epoxy-4-methyl-1-phenylpentan-1-one (187742-13-8) + ((2R,3S)-3-isopropyloxiran-2-yl)(phenyl)methanone + anti-2-chloro-3-hydroxy-4-methylpentanophenone + anti-2-chloro-3-hydroxy-4-methylpentanophenone (229180-32-9) + 2-chloro-3-hydroxy-4-methyl-1-phenylpentan-1-one

Guidance literature:

With lithium hydroxide; N-[4-(trifluoromethyl)benzyl]cinchoninium bromide; In dibutyl ether; at 4 ℃; for 10h; Product distribution; Mechanism; other time;

DOI:10.1016/S0040-4020(99)00213-6

upstream raw materials:

1-chloroacetophenone

isobutyraldehyde