2293-75-6

Basic information

• Product Name: 2-METHOXYPHENYL CHLOROFORMATE
• Synonyms: 2-METHOXYPHENYL CHLOROFORMATE;2-Methoxyphenyl carbonochloridate
• CAS NO: 2293-75-6
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 2293-75-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 244 °C(lit.)
• Flash Point: 110 °C
• Appearance: /
• Density: 1.253 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0322mmHg at 25°C
• Refractive Index: n20/D 1.519(lit.)
• CAS DataBase Reference: 2-METHOXYPHENYL CHLOROFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYPHENYL CHLOROFORMATE(2293-75-6)
• EPA Substance Registry System: 2-METHOXYPHENYL CHLOROFORMATE(2293-75-6)

Safety Data

• Hazard Codes: T,C
• Statements: 25-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3277 6.1/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 2293-75-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7ClO3/c1-11-6-4-2-3-5-7(6)12-8(9)10/h2-5H,1H3

Upstream product

• 75-44-5 phosgene 
• 13052-77-2 sodium 2-methoxyphenolate 
• 90-05-1 2-methoxy-phenol 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 103155-04-0 carbonic acid-(5-acetyl-[8]quinolyl ester)-(2-methoxy-phenyl ester) 
• 75-44-5 phosgene 
• 553-17-3 bis(2-methoxy-phenyl)carbonate 
• 33274-93-0 phenyl-carbamic acid-(2-methoxy-phenyl ester) 
• 115798-72-6 N-(2-methoxy-phenoxycarbonyl)-alanine 
• 120971-58-6 O¹,O²,O³,O⁶-Tetrakis-(2-methoxy-phenoxycarbonyl)-O⁴-[tetrakis-O-(2-methoxy-phenoxycarbonyl)-β-D-galactopyranosyl]-ξ-D-glucopyranose 
• 1079051-71-0 2-methoxyphenyl 4-(4-(4-cyano-2-fluorophenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate 
• 1226787-22-9 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-1,3-dicarboxylic acid 3-ethyl ester 1-(2-methoxy-phenyl) ester 
• 1419026-41-7 (S)-(+)-1-phenyl-1-(2-methoxyphenoxy)-2-propene 
• 1419028-11-7 trans-hex-2-enyl 2-methoxyphenyl carbonate 
• 1312335-38-8 C₃₈H₄₈N₂O₆ 

Relevant articles and documents

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents

In our previous research, a novel series of phenylsulfonyl hydrazide derivatives were found to reduce LPS-induced PGE2levels in RAW 264.7 macrophage cells via an inhibition of mPGES-1 enzyme. Recently, it was found that a regioisomeric mixture of phenylsulfonyl hydrazide was formed depending on the reaction conditions, which favor either of two regioisomers. One regioisomer corresponds to a kinetic product (7a–7c) and the other regioisomer corresponds to a thermodynamic product (8a–8c). Among them, the structure of kinetic product 7b was confirmed by measuring single X-ray crystallography. In vitro PGE2assay studies showed that the kinetic product (7a and 7b; IC50= 0.69 and 0.55 μM against PGE2) is generally more potent than the thermodynamic product (8a and 8b; IC50= >10 and 0.79 μM against PGE2). A molecular docking study also exhibited that the kinetic product (7a) has a higher MolDock Score (?147.4) than that of 8a (?142.4), which is consistent with the PGE2assay results. A new potent phenylsulfonyl hydrazide (7d; IC50= 0.06 μM against PGE2) without affecting COX-1 and COX-2 enzyme activities was identified based on these overall results.

Substituted acid derivatives useful as antidiabetic and antiobesity agents and method

Compounds are provided which have the structure wherein Q is C or N, A is 0 or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.