22932-27-0

Basic information

• Product Name: 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol
• Synonyms: 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol
• CAS NO: 22932-27-0
• Molecular Weight: 251.756
• Mol File: 22932-27-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol(22932-27-0)
• EPA Substance Registry System: 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol(22932-27-0)

Safety Data

• Hazardous Substances Data: 22932-27-0(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 532-24-1 tropinone 
• 532-24-1 tropinone 

Downstream Products

• 22932-21-4 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ene 
• 912641-08-8 3-(4-chloro-phenyl)-8-aza-bicyclo[3.2.1]oct-2-ene 
• 1295650-27-9 (+)-methyl (1R,2S)-2-{[(3-endo)-3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]methyl}-1-phenylcyclopropanecarboxylate 
• 1295650-32-6 (+)-methyl (1R,2S)-2-{[(3-endo)-3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]methyl}-1-phenylcyclopropanecarboxylate oxalate 
• 1297320-51-4 (-)-methyl (1S,2R)-2-{[(3-endo)-3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]methyl}-1-phenylcyclopropanecarboxylate 
• 1297320-53-6 (-)-methyl (1S,2R)-2-{[(3-endo)-3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]methyl}-1-phenylcyclopropanecarboxylate oxalate 
• 1295650-28-0 methyl (1R,2S)-2-{[(1R,5S/1S,5R)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]methyl}-1-phenylcyclopropanecarboxylate 
• 1295650-33-7 methyl (1R,2S)-2-{[(1R,5S/1S,5R)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]methyl}-1-phenylcyclopropanecarboxylate oxalate 
• 1295650-30-4 methyl (1S,2R)-2-{[(1R,5S/1S,5R)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]methyl}-1-phenylcyclopropanecarboxylate 
• 1295650-35-9 methyl (1S,2R)-2-{[(1R,5S/1S,5R)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]methyl}-1-phenylcyclopropanecarboxylate oxalate 
• 637311-69-4 (3-endo)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol 

Relevant articles and documents

Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties

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Azabicycloalkane derivatives for use as serotonin reuptake inhibitors and 5ht2a antagonists

The present invention is directed to a compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, Y, U, W, k, A, E, V, R4 and R5 are as defined herein, pharmaceutical compositions thereof, and methods of use thereof in the inhibition of serotonin reuptake, the inhibition of the binding of 5-HT2A serotonin receptors and the treatment of diseases, conditions or disorders of the central nervous system. Further, the present invention is also directed to methods for the preparation of compounds of formula (I) and intermediates useful therefor.

8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use

PCT No. PCT/EP96/04449 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Oct. 11, 1996 PCT Pub. No. WO97/13770 PCT Pub. Date Apr. 17, 1997A compound having the formula, or any of its enantiomers or any mixture thereof, or a pharmaceutical