22936-96-5Relevant articles and documents
Trienediolates of hexadienoic acids in synthesis, synthesis of retinoic and nor-retinoic acids
Aurell, Maria J.,Carne, Ismael,Clar, Jose E.,Gil, Salvador,Mestres, Ramon,Parra, Margarita,Tortajada, Amparo
, p. 6089 - 6100 (1993)
Double deprotonation of either (E,E)-3-methyl-2,4-hexadienoic acid 2, or 4,6-dimethyldihydro-2-pyrone 3 generates apparently the same lithium trienediolate, which affords ω-hydroxy acids 9 on reaction with ketones 7. Hydroxy acids 9 are easily dehydrated to octatrienoic acids 5, which are structurally related to retinoic acid. Similarly, sorbic acid 1 leads to nor-retinoic acid analogs 6.