4985-92-6

Basic information

• Product Name: 2-FORMYL-5-PICOLINE
• Synonyms: 5-METHYL-2-PYRIDINALDEHYDE;2-FORMYL-5-PICOLINE;5-Methylpyridine-2-carboxaldehyde;5-Methylpicolinaldehyde;5-Methylpyridine-2-carboxaldehydet;2-Pyridinecarboxaldehyde,5-Methyl-;5-methyl-2-pyridinecarboxaldehyde
• CAS NO: 4985-92-6
• Molecular Formula: C₇H₇NO
• Molecular Weight: 121.14
• Product Categories: Pyridine;Pyridines;Heterocycle-Pyridine series
• Mol File: 4985-92-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 41.5 °C
• Boiling Point: 208.781 °C at 760 mmHg
• Flash Point: 84.245 °C
• Appearance: /
• Density: 1.095 g/cm³
• Vapor Pressure: 0.21mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: 2-FORMYL-5-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYL-5-PICOLINE(4985-92-6)
• EPA Substance Registry System: 2-FORMYL-5-PICOLINE(4985-92-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 4985-92-6(Hazardous Substances Data)

Usage

General Description

2-Formyl-5-Picoline is a chemical compound with the molecular formula C7H6NO and a molar mass of 122.13 g/mol. It is a derivative of pyridine and is commonly used as a building block in organic synthesis. 2-FORMYL-5-PICOLINE is a yellow solid and is soluble in organic solvents such as acetone and methanol. 2-Formyl-5-Picoline is often used in the production of pharmaceuticals, agrochemicals, and as a reagent in various chemical reactions due to its versatile nature and reactivity. It plays an important role in the development of new organic compounds and materials.

InChI:InChI=1/C7H7NO/c1-6-2-3-7(5-9)8-4-6/h2-5H,1H3

Upstream product

• 589-93-5 2,5-dimethylpyridine 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 661458-29-3 5-methyl-2-pyridylmagnesium bromide 
• 1121-60-4 pyridine-2-carbaldehyde 
• 4986-05-4 2,5-dimethylpyridine N-oxide 
• 55876-82-9 5-methyl-2-pyridinecarboxylic acid-ethyl ester 
• 1620-77-5 5-methylpicolinonitrile 
• 22940-71-2 2-hydroxymethyl-5-methylpyridine 
• 3430-13-5 5-bromo-2-methylpyridine 
• 772-71-4 2-acetoxymethyl-5-methyl pyridine 

Downstream Products

• 647840-29-7 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-(5-methyl-2-pyridyl)propionate 
• 647840-28-6 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-methyl-2-pyridyl)-2-triisopropylsilyloxypropionate 
• 1149761-69-2 N-(1-benzoyl-4-fluoropiperidin-4-yl)methyl-N-(5-methylpyridin-2-yl)methylamine 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 849661-64-9 C₂₇H₂₄N₄ 
• 675137-68-5 N-(4-dipropylaminomethylphenyl)-4-{[(5-methylpyridin-2-ylmethyl)amino]methyl}benzamide 

Relevant articles and documents

Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning

Organophosphorus nerve agents (OPNAs) inhibit acetylcholinesterase (AChE) and, despite the Chemical Weapons Convention arms control treaty, continue to represent a threat to both military personnel and civilians. 2-Pralidoxime (2-PAM) is currently the only therapeutic countermeasure approved by the United States Food and Drug Administration for treating OPNA poisoning. However, 2-PAM is not centrally active due to its hydrophilicity and resulting poor blood-brain barrier permeability; hence, these deficiencies warrant the development of more hydrophobic analogs. Specifically, gaps exist in previously published structure activity relationship (SAR) studies for 2-PAM, thereby making it difficult to rationally design novel analogs that are concomitantly more permeable and more efficacious. In this study, we methodically performed a methyl scan on the core pyridinium of 2-PAM to identify ring positions that could tolerate both additional steric bulk and hydrophobicity. Subsequently, SAR-guided molecular docking was used to rationalize hydropathically feasible binding modes for 2-PAM and the reported derivatives. Overall, the data presented herein provide new insights that may facilitate the rational design of more efficacious 2-PAM analogs.

Deuterium-Substituted Pyridin- And Pyrimidin-2-yl-Methylamine Compounds

Described are deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds of structural Formula (I), which are agonists of 5-hydroxytryptamine receptors. Also described are pharmaceutical compositions comprising the deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds, and methods of use thereof.

Confined Pyrolysis within Metal-Organic Frameworks to Form Uniform Ru3 Clusters for Efficient Oxidation of Alcohols

Here we report a novel approach to synthesize atomically dispersed uniform clusters via a cage-separated precursor preselection and pyrolysis strategy. To illustrate this strategy, well-defined Ru3(CO)12 was separated as a precursor by suitable molecular-scale cages of zeolitic imidazolate frameworks (ZIFs). After thermal treatment under confinement in the cages, uniform Ru3 clusters stabilized by nitrogen species (Ru3/CN) were obtained. Importantly, we found that Ru3/CN exhibits excellent catalytic activity (100% conversion), high chemoselectivity (100% for 2-aminobenzaldehyde), and significantly high turnover frequency (TOF) for oxidation of 2-aminobenzyl alcohol. The TOF of Ru3/CN (4320 h-1) is about 23 times higher than that of small-sized (ca. 2.5 nm) Ru particles (TOF = 184 h-1). This striking difference is attributed to a disparity in the interaction between Ru species and adsorbed reactants.