2296-14-2

Upstream product

• 854840-04-3 chloro-dioctyl-amine 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 111-86-4 n-Octylamine 
• 124-13-0 Octanal 
• 10576-04-2 N-n-octylidene-n-octylamine 
• 1120-48-5 n-dioctylamine 
• 6312-43-2 2-dioctylamino-1-(6-methoxy-2-phenyl-[4]quinolyl)-ethanol; dihydrochloride 

Downstream Products

• 55255-61-3 nitro-dioctyl-amine 
• 85866-42-8 Dioctylcyanamide 

Relevant academic research and scientific papers

TERTIARY AMINE COMPOUND AND COBALT EXTRACTANT CONTAINING TERTIARY AMINE COMPOUND

PROBLEM TO BE SOLVED: To provide a cobalt extractant having high cobalt extraction rate in a solvent extraction of cobalt from a solution containing the cobalt, and less in production amount of a decomposition product insoluble in an aromatic hydrocarbon solvent causing clad. SOLUTION: There are a tertiary amine compound represented by the following formula (1), and a cobalt extractant containing the tertiary amine compound. Formula (1) In the formula, R1 and R2 represent an alkyl group having 8 to 11 carbon atoms, which may have a branched structure, but excluding cases that both of R1 and R2 are 1-methyl heptyl groups, and that both of R1 and R2 are 2-ethylhexyl groups. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Designing Simple Lipidated Lysines: Bifurcation Imparts Selective Antibacterial Activity

In the global effort to thwart antimicrobial resistance, lipopeptides are an important class of antimicrobial agents, especially against Gram-negative infections. In an attempt to circumvent their synthetic complexities, we designed simple membrane-active agents involving only one amino acid and two lipid tails. Herein we show that the use of two short lipid tails instead of a single long one significantly increases selective antibacterial activity. This study yielded several selective antibacterial compounds, and investigations into the properties of this compound class were conducted with the most active compound. Fluorescence spectroscopic studies revealed the capacity of the representative compound to cause depolarization and permeabilization of bacterial cell membranes. This membrane-active nature of the compound imparts superior activity against persister cells, biofilms, and planktonic cells. Topical application of the compound decreased bacterial burden in mice inflicted with burn-infections caused by Acinetobacter baumannii. We anticipate that the design principles described herein will direct the development of several antimicrobial agents of clinical importance.